The Expressions And Significance Of MIF、p-mTOR And EMT Molecules In Cervical Cancer Tissues

Objective:1 The Meta analysis method was applied to analyze the role of MIF in m alignant tumor.2 The Meta analysis method was used to analyze the role of m TOR in ce rvical cancer.3 Exploring whether MIF can promote EMT in cervical cancer tissue by m TOR signal pathway.Methods:1 According to the related rules in and out, to retrieve researches about M IF expression in malignant solid tumor that were obstained in the database,such as Medline, Embase, Pubmed and Web of Science and The Cochrane Library during a certain period,then using Revman5.2 software to integrate and analyze the relationship between MIF expression and clinical pathological characteristics and survival among patients who were survived malignant solid tumors;2 The same to procedure 1 to integrate and analyze the relationship betwe en m TOR expression and clinical pathological characteristics among cervical can cer patients;3 Applying the immunohistochemical staining(streptavidin biotin- peroxida se complex method, SABC method) to detect the dynamic expression of MIF,p-m TOR and EMT related molecules in normal cervix tissues,CINII-III tissues a nd cervical cancer tissues.Results:1 Expression of MIF is significantly higher in lymph node metastasis grou p, higher pathologic stage group and recurrence after tumor resection group tha n control groups; At the same time, the expression of MIF can significantly re duce the OS in patients with malignant solid tumors; In addition, among Asian population, MIF high expression can significantly reduce the OS of patients wi th small cell lung cancer.2 Expression of m TOR is significantly higher in cervical cancer tissues tha n normal cervix and CINII-III tissues; higher in lymph node metastasis, higher clinical stage and the radiation and chemotherapy response negative group.3 The expression of MIF was rising from normal cervical tissue, CINII-III tissues to cervical cancer tissue expression of rising step by step; in cervical c ancer tissues, the expression of MIF was positively related with p-m TOR and Vimentin,and negatively related with E-cadherin;the expression of p-m TOR was positively related with Vimentin,and negatively related with E-cadherin.Conclusions:1 MIF can promote the development of malignant solid tumor, lessen the s urvival outcomes for patients with malignant tumor;2 m TOR can devote to the promotion of cervical lymph node metastasis a nd reduce the radiation and chemotherapy response to accelerate the developme nt of cervical cancer;3 MIF can promote EMT in cervical cancer tissues by m TOR signal path way.