3D-ASL MRI Perfusion Technique In The Application Value Of Brain Tumor

Objective:To compare the difference between 3D-ASL and dynamic susceptibility-weighted contrast magnetic resonance imaging(DSC-MRI)for evaluation of tumor blood flow(TBF) in patients with brain tumors.And to study the three-dimensional arterial spin labeling(3D-ASL) whole brain perfusion imaging in the diagnosis of brain tumor and application value of classification.Methods:Firstly,retrospectively analyzed brain tumors(n=34, 20 mem and 14 women; mean age: 51;range 15 to 72) to used 3D-ASL and DSC-MRI in patients with histopathologically proved. All patients underwent routine MRI(T1WI、T2WI、FLAIR),3D-ASL,DSC-MRI and contrast enhancement T1WI(CE-T1WI)scans on Siemens Magnetom Skyra 3.0T. Use of the region of interest(ROI) method to obtained Relative tumor perfusion ratio.A quantitative analysis was performed with relative tumour perfusion values(ASL r TBF, DSC r TBF),r TBF is calculated by dividing tumour blood flow obtained from tumors mirror region, contralateral normal gray matter,contralateral normal white matter.Mirror region refers to the tumors of the contralateral corresponding brain regions. ASL r TBF measurements and DSC r TBF was compared by Paired T tests,difference was statistically significant(P<0.05).Correlation analyze were applied to evaluate the correlations among quantitative results.Secondly, retrospective analysis confirmed by histopathological and immunhistochemical of 40 cases of brain tumors, including 14 cases of gliomas(6cases with low grade gliomas and 8 high grade glioma), 6 cases of myeloid sarcoma, 10 cases of meningioma and metastatic tumor, respectively. Measure 3D-ASL cerebral blood flow perfusion image tumor substantial part of the largest value(TBFmax), the contralateral normal white matter of cerebral blood flow(CBF) value and the relative tumor blood flow(r TBF).r TBF = TBFmax/CBF. Glioma were divided into low and high grade, meningioma, metastatic tumor group and myeloid sarcoma group, using the single factor analysis of variance of r CBF value comparison between groups, using the snk-q test to compare two,difference was statistically significant(P<0.05).Results:One(1)The absence of significant differences between ASL r TBF and DSC r TBF when contralateral normal gray matter,normalized to mirror region(P=0.096 and0.108, respectively).But when normalized to contralateral normal white matter, it had significant difference.(2) There was a highly significant correlation between ASL r TBF and DSC r TBF(R=0.946, 0.911 and 0.744 respectively) When tumors mirror region, contralateral normal gray matter and contralateral normal white matter as the reference standard.Two The r CBF of 3D-ASL was obtained quantitative magnetic resonance perfusion imaging parameters, quantitative r TBF myeloid sarcoma group were lower than low grade glioma group, the high grade glioma group, metastatic tumors and meningiomas group, the differences were statistically significant;r TBF low grade glioma group were lower than the group of high grade glioma, meningioma and metastases group,the differences were statistically significant; high grade glioma, meningioma,and among metastases was no statistically significant difference.Conclusion:3D-ASL perfusion technique can be used as a non-invasive magnetic resonance method in the evaluation of perfusion in brain tumours.3D-ASL can quantitatively reflect the perfusion of the tumor microcirculation, diagnosis,differential diagnosis and classification of brain tumors has important value.