Early Morning Short-term Blood Pressure Variability Research In The Acute Ischemic Stroke Patients With Internal Carotid Artery Stenosis

Objective:This paper mainly discusses the characteristics of the early morning short-term blood pressure variability in acute ischemic cerebral stroke patients with internal carotid artery stenosis.Methods:This is a prospective study,the patients with acute ischemic stroke and internal carotid artery stenosis were chosen for study, who were treated in neurology department Changzhi People’s Hospital from January 2013 to January 2015.The patients with internal carotid artery stenosis were screened out by noninvasive examination firstly, then confirmed by DSA.According to the degree of stenosis,the patients were divided into three groups according to the degree of stenosis(stenosis rate from 70% to 99% as severe stenosis groupustenosis rate from 50% to 69% as moderate stenosis groupustenosis rate<50% for no significant stenosis group).From the second day in hospital,measures of the patients’ blood pressure were took in the early morning,continuous observation was made on those patients until three months later after they leave the hospital.We then collected datas of the patient’s blood pressure,standard deviation of blood pressure is used to indicate the blood pressure variability. We compared the general condition of patients in the three groups, and analyzed the average morning systolic blood pressure and morning diastolic blood pressure of patients in the three groups during the 3 months, and analyzed the variabilty of systolic blood pressure and diastolic blood pressure in the early morning.Results:79 cases of acute ischemic stroke patients with internal carotid artery stenosis were chosen, according to the degree of stenosis, patients were divided into three groups,stenosis rate from 70% to 99% as severe stenosis group(group A) contained 20 cases,stenosis rate from 50% to 69% as moderate stenosis group(group B) contained 19 cases,stenosis rate<50% for no significant stenosis group(group C) contained 40 cases.1.Comparison was made among the 3 groups, systolic blood pressure variability in the early morning difference was with statistical significance(F = 62.581, P = 62.581),diastolic blood pressure variability in the early morning difference was with statistical significance(F = 0.003, P = 0.003), the average systolic blood pressure difference was with statistical significance(F = 15.959, P < 0.001), the average diastolic blood pressure difference was no statistical significance(F = 1.705, P = 0.189).2.Comparing group A and group B, systolic blood pressure variability in the early morning difference was with statistical significance(t=5.777,P = 0.0012), diastolic blood pressure variability in the early morning difference was with statistical significance(t=3.466,P = 0.011), the average systolic blood pressure difference was with statistical significance(t=4.60,P < 0.0001).3.Comparing group A and group C, systolic blood pressure variability in the early morning difference was with statistical significance(t=11.260,P = 0.0001), diastolic blood pressure variability in the early morning difference was with statistical significance(t=5.574,P = 0.015), the average systolic blood pressure difference was with statistical significance(t=4.863,P < 0.0001).4.Comparing group B and group C, systolic blood pressure variability in the early morning difference was with statistical significance(t=4.206,P = 0.001).Conclusion:1. For the Ischemic stroke patients with internal carotid artery stenosis, there early morning blood pressure variability was positively correlated with the degree of the internal carotid artery stenosis. and the narrower the blood vein is, the bigger the fluctuation is.2. For the Ischemic stroke patients with internal carotid artery severe stenosis compared with patients with no significant stenosis, the average systolic blood pressure in the early morning were slightly higher.