The Impact Of ω-3 Fatty Acids On Inflammation And Nutritional Status In Patients With Gastric Cancer After Laparoscopic Gastric Surgery

Objective: this topic is to investigate the effect on parenteral nutrition which contain omega-3 polyunsaturated fatty acids to the inflammation, nutrition status in the patients with laparoscopic gastric cancer surgery.Methods: choose the patients who had laparoscopic gastric cancer surgery in Gansu Provincial Hospital during 2013-12and2015-12.It included one hundred patients which randomly divided into two groups: control group(n=50) and trail group(n=50). The nutrition support is at least five days. the trail group received fish oil. The levels of serum CRP,LTB4,LTB5,IL-6,N,WBC,PCT and some nutritional indicators(total protein, albumin, globulin,hemoglobin, oxygen saturation, prognostic inflammatory and nutritional index were detected on the 1 day pre-operation and on first, third, fifth day after operation.Results:inflammatory indicators: In the first day of pre-operation, the CRP, IL- 6, PCT, WBC, N and LTB5 / LTB4 respectively compared with the control group did not have statistical difference(P>0.05).In the first, third and fifth day of post-operation, the CRP, IL-6, PCT in experimental group were lower than the control group(P < 0.05).In the third and fifth day after surgery, the CRP, IL-6, PCT in experimental respectively compared with control group were lower(P<0.05), while the LTB5 / LTB4 were higher(P<0.05)nutritional indexes: In the first day of pre-operation, the TP, GLB, HB, SaO2, ALB, LY and INI respectively compared with the control group did not have statistical difference(P>0.05).In the first and fifth day after surgery, the TP, ALB, INI in experimental were higher(P<0.05).In the third day after surgery, the LY、INI in experimental were higher compared with control group(P<0.05).And in the fifth day after surgery, the HB in experimental was also higher(P<0.05),Conclusions:1. In patients with laparoscopic gastric cancer surgery, add omega-3 polyunsaturated fatty acids to parenteral nutrition can reduce inflammatory factors, for example CRP、IL-6、PCT, and increase the number of LTB5/LTB4,so it can improve inflammatory reaction.2. Laparoscopic postoperative patients with gastric cancer effect, add omega-3 polyunsaturated fatty acids to parenteral nutrition can significantly improve the nutritive condition of patients, slow down the consumption of ALB.