The Application Of Uterine Fibroid On Magnetic Resonance Diffusion Tensor Imaging

PART 1A STUDY OF DIFFUSION TENSOR IMAGINGCHARACTERISTICS OF UTERINE FIBROIDS WITHHOMOGENEOUS HYPOINTENSE SIGNAL ON T2WIObjective To observe the of DTI parameter variations of uterine fibroids with homogeneous hypointense signal on T2 WI with normal muscle layers, and the difference of DTI parameters between fibroids at different location.methods 65 patients with uterine fibroids were performed pelvic routine MRI scanning, enhanced scanning and DTI scan. 80 uterine leiomyomas were analyzed, including 42 intramural hysteromyoma and 38 subserous fibroids. The fractional anisotropy(FA), mean diffusivity(MD)and relatively anisotropy(RA) of all lesions and normal muscle layers were calculated, all data were analyzed through Independent-Samples T Test by SPSS19.0.Results MD values of hysteromyomas with homogeneous hypointense signal on T2 WI was(1.275±0.204)×10-3mm2/s,which wassignificantly lower than the myometrium, FA values(0.465±0.114) and RA values(0.420±0.110) were higher than the myometrium,but there was no significant difference between the parameters of subserous fibroids and intramural hysteromyoma.Conclusion The DTI characteristics of uterine fibroids with homogeneous hypointense signal on T2 WI had some characteristics, which were different with the normal muscle layer,and the location of hysteromyoma did not have much effect on the characteristics of DTI.PART 2FEASIBULITY STUDY OF DTI FIBRE TRACTOGRAPHYAPPLIED TO UTERINE FIBROIDS IN VIVOobjective To explore the feasibility of MR diffusion tensor imaging(DTI) fibre tractography applied to uterine fibroids in vivo, and compare the difference of related DTI measurements between the ordinary leiomyomas and e-xtraordinary uterine fibroids.methods 24 patients with 36 uterine fibroids were performed pelvic routine MRI scanning and DTI scan at a 3.0T MRI scanner, 21 ordinary leiomyomas,15 extraordinary uterine fibroids.the apparent diffusion coefficient(ADC) value, Fractional anisotropy(FA) value,density of fiber bundle, length of the longest fibre bundle and the average length of fibre bundles were measured and collected. The comparison of all data between the ordinary leiomyomas and extraordinary uterine fibroids were analyzed using Independent-Samples T-test.Results Satisfactory reconstruction images of all uterine fibroids were obtained, and the ordinary leiomyomas:ADC values=(1.479±0.214)× 10-3 mm2/s, FA values=0.317 ± 0.085, the density of fiber bundles is130.524 ± 56.549 strip/ml, the ratio between the length of longest fibre bundle or the average length of fibre bundles and the large-st diameter of leiomyomas is 1.405±0.418、0.318±0.090; the extraordinary leiomyomas:ADC values=(1.706±0.308)×10-3 mm2/s,FA values=0.261±0.053,the density of fiber bundles is 137.333±43.483strip/ml,the ratio between the length of longest fibre bundle or the average length of fibre bundles and the largest diameter of leiomyomas is 0.983±0.247、 0.210±0.060.the ADC values of ordinary leiomyomas was significant lower than the extraordinary(P=0.013), FA values was significant higher than the extraordinary(P=0.031), the density of fiber bundles between two types uterine fibroids had no significant difference(P=0.699),the ratio between the length of longest fibre bundle or the average length of fibre bundles and the largest diameter of leiomyomas in ordinary fibroids was significant larger than the extraordinary(P=0.001、0.000).Conclusion DTI fiber technology applied to reconstructing fiberbundles of uterine fibroids was feasible,and the ADC values、FA values、length of fibre bundles of leiomyomas with different pathological type were significant difference, which were consistentedwith the microscopic a-ppearance.