The Clinical Significance Of Serum PSA Level In Patients With Prostate Biopsy

Objective: To explore the clinical value of serum PSA level in the patients with prostate biopsy.Methods: The patients who had undergone trans rectal core biopsies of the prostate by ultrasound guided from 2013.01 to 2014.12 at The First Affiliated Hospital of Chongqing Medical University. Collecting their serum PSA level, pathological results,bone scintigraphy,etc. The patients were divided into four groups, namely A(PSA≤4.0ng/ml) 、 B(4.0ng/ml <PSA≤10.0ng/ml)、C(10ng/ml<PSA≤20ng/ml)、D(PSA>20.0ng/ml). The positive biopsy rates or the rate of bone metastases in each group compared with each other by Chi-square test. The Spearman rank correlation was used to evaluate the correlation ship between serum PSA concentration and pathological grade.Results: The prostate positive biopsy rates in group with A、B、C、D was 9.09%、9.83%、26.21%、74.73%, respectively; Groups of the prostate positive biopsy rates were compared with each other, except A vs B、A vs C has no statistically significant difference(P > 0.05), the others compared with each other had statistical significance(P < 0.05). The prostate positive biopsy rate was no statistically significant difference between f/tPSA≤0.16 and f/tPSA > 0.16 in the group with B(P=0.869).The rate of bone metastases has significant statistical significance between PSA>20ng/ml and PSA≤20ng/ml in prostate cancer patients(P=0.000).The PSA concentration has uncertainly negative correlation with the tumor differentiation(r=﹣0.131 P=0.141).Conclusions: The higher the serum PSA level, the higher positive biopsy rate of prostate; When the first diagnosis of prostate cancer patients with serum PSA > 20.0ng/ml, the radionuclide bone scans should be suggested; Serum PSA level and prostate tumor differentiation degree has no correlation.