Studies On Synthesis And Subsequent Conversion Reaction Of Amide-substituted Enyne Ester Derivatives

There are three parts in this thesis, the first part is gold and silver co-catalyzed synthesis of polysubstituted pyrrole derivatives, the second part is iodine-promoted synthesis of furanone derivatives, the third part is the study of coupling reaction of Salicylaldehyde and vinyl iodides.In part one, firstly, we synthesized a series of amide-substituted enyne ester derivatives. Then we developed a novel procedure catalyzed by Au/Ag for the synthesis of multi-substituted pyrrole derivatives via intramolecular cyclization from readily available compounds in good yields. The transformation tolerates extensive substitution. Twelve compounds were synthesized, and one of which was characterized by X-ray single crystal diffraction.In part two, we developed an iodine promoted intramolecular cyclization for the formation of multi-substituted furanone derivatives from amide-substituted enyne ester compounds in moderate yields. Twelve compounds were synthesized, and one of which was characterized by X-ray single crystal diffraction.In part three, we developed a cascade reaction of salicylaldehyde with vinyl iodides, Further studies are on the way in our laboratory.All new compounds were characterized by1H NMR,13C NMR. and HRMS spectroscopy.