Synthesis Of 3-Trifluoromethyl Acetophenone

3-(Trifluoromethyl) acetophenone is one important intermediate in the preparation of Trifloxystrobin, which is a highly effective and safe fungicide. It is also an intermediate for the preparation of pharmaceuticals and dyes.The known processes for the preparation of 3-(trifluoromethyl) acetophenone are unsatisfactory for economic, ecological and safety reasons. We studied two feasible routes in order to find out the optimized procedure with low cost, high yield and less pollution.Route 1:3-(Trifluoromethyl)acetophenone was synthesized from m-trifluoromethylphenylamine, via diazotization, coupling reaction and hydrolyzation. Effects of temperature, catalyst, time, ration, pH value and solvent were studied. The yield was above 81.2%.Route 2:3-(Trifluoromethyl)acetophenone was prepared by Grignard reaction of 3-bromobenzotrifluoride. Effects of temperature, time, ration and solvent were studied. The yield was above 82.0%.The methods provided herewith are distinguished by ready availability of the raw materials, good technical feasibility and is economically and ecologically favorable.