Adsorption And Separation Of Chiral Drugs(S)-Naproxen With Novel Surface Molecularly Imprinted Polymer

Chiral drugs are closely related to our lives and health. More than 50 percents of clinical drugs have chiralty. Scientific research and clinical practice shows that chiral factors of the molecular structure of chiral drugs will make pharmacological activity of chiral enantiomer different. In recent years, the development of pure chiral drugs has attracted much attention in many countries. The exploitation of new drugs is an arduous, costly and high-risk task. However, splitting the racemic drugs is a efficient tool to avoid the disadvantages mentioned above. Therefore, it is great significance to develop a simple, low-cost method for the separation of enantiomers which is easy access to industrial application. The main topic of this paper is the research of the adsorption separation based on a non-steroidal anti-inflammatory drug, naproxen, which employed surface-controlling molecular imprinting porous silica, ?-cyclodextrin-grafting magnetic nanoparticle and thermosensitive magnetic molecular imprinting. The detail works are described as follows:1?A molecularly imprinted polymer porous silica for S-naproxen was prepared. We optimized the reaction conditions of the imprinted polymer and the results showed that when the ratio of target molecule and functional monomer was 2:3, the ratio of monomer and cross-linking agent was 10:3 and the adsorption solvent was chlorobenzene, the maximum of molecularly imprinted materials was 6.998 mg/g, the linearly dependent coefficient R2 = 0.922 and the separation factor reached 1.50 according to the Langmuir model.2??-CD/Fe3O4@SiO2 was obtained after grafting the modified ?-cyclodextrin to the iron nanoparticles. When pH = 7.0, T = 30 oC, t = 150 min, c = 15 mg/m L, the adsorption capacities of the target material to(S)-naproxen reached the best. The simulative Langmuir adsorption indicated that the maximum of the adsorption capacities reached 43.011 mg/g, the linearly dependent coefficient R2 = 0.997.3?The thermosensitive magnetic molecularly imprinted polymer particles were synthesized by the combination of the thermosensitive intelligent materials and the specific molecular imprinting techniques, which were characterized by SEM and IR spectra. We next investigated the thermosensitive polymer hydrogel and the results revealed that the ratio of target molecules, thermosensitive monomer and functional monomer was 1:4:1, the crosslinker percentage was 0.6% gave the adsorption and swelling properties of gel particles the best result. When pH = 7.4, T = 15 oC, t = 60 min, c = 10 mg/m L, the adsorption capacities got the best result. the linearly dependent coefficient of Langmuir model R2 = 0.983, the maximum of the adsorption capacities was 24.820 mg/g. The selective experiments proved that the molecularly imprinted polymer hydrogel had good selectivity and the ee% of NIPs was 0.69% while the ee% of MIPs was 12.25%.