Palladium Catalyzed Asymmetric 1,6- Addition Of Diarylphosphines To Unsaturated Carboxylic Acid Esters

As a member of the thousands of chiral compounds, chiral phosphines not only in pesticide and medicine play an important role, but also as one of the most important ligands in organometallic synthesis, its effect has become increasingly prominent. Although there are many reported methods for the synthesis of chiral phosphorus compounds, but asymmetric catalytic preparation is a kind of method of more concise and efficient, and the construction of carbon phosphorus bond via asymmetricis catalysis one of the important ways. In order to enrich the methods for the preparation of chiral phosphine compounds, We developed a new method for the synthesis of chiral phosphorus olefin compounds.Palladium-catalyzed 1,6-addition of diarylphosphines to ?, ?,?y,?-unsaturated carboxylic esters was developed for synthesis of chiral phosphine compounds. The chiral allylic phosphine derivatives were synthesized in moderate yields with excellent enantioselectivity at room temperature without addition of base.