Synthesis And Application Of Di-[1,2,3]-triazoles Modificated Compounds

CuAAC reaction in which azide and terminal alkyne react to give 1,2,3-triazole under copper catalysis,has been widely used in drug discovery,materials science,biochemistry and other branches of chemistry since it was reported by Sharpless and Medal in 2002.With the development of CuAAC reaction,it was found that: copper plays a very important role in the precedure of the reaction,but the toxicity of Cu(I)as we know has slow down its development in the living systems.Further,the slow reaction rate of CuAAC in many cases is not desirable.In order to improve biocompatibility of CuAAC,reduce the toxicity of copper(I)in living systems,two new research areas have attracted the great interest.One is copper-free click reaction(SPAAC reaction),the other is ligand-accelerated CuAAC reaction.This article is mainly focused on the ligand-accelerated click reaction,and the following four parts are included:First,description of the latest development of CuAAC coupling reaction in term of the applications in living system,and the ligands of Cu AAC reaction.Second,development of a new reaction to synthesize 7-membered ring compounds through in situ constructing intermolecular SP~2 carbon-carbon bond between triazolyl copper(I).Third,development of the new class of ligands derived from amino acid which can efficiently accelerate CuAAC reaction.Besides,the application of the newly synthesized ligands was taken.Further the modifications of the ligand and their applications ate still underway.