| The 1,3,5-triarylpentane-1,5-diones compounds is not only the starting material of the functional heterocyclic compounds and organic polymer materials compounds, it also have a very wide range of applications in coordination chemistry, molecular chemistry and determination, and biology correction electrodes. There are many kinds of methods for the synthesis of 1,3,5-tris-aryl-1,5-diketones in the early stage, but most of the methods are not perfect, some used the precious metal catalyst, some have harsh reaction conditions, some of it material is difficult to produce, so to search for a more comprehensive approach to the preparation of 1,3,5-tris-aryl-1,5-dione of great significance.3,5-diarylisoxazoles compounds, very concerned by chemists because of its containing C-O bond and special unsaturated double bonds. In recent years, found that it has been widely used not only in medicine, but also in the field of pesticides and insecticides. Thus, for its synthesis also of great significance.This paper is based on research the new methods of chalcones as substrates, synthesis of 1,3,5-triarylpentane-1,5-diones respectively in the condition of copper-mediated and 3,5-diarylisoxazoles metal-free catalyzed.The paper is divided into the following aspects:Chapter One: A Summary of the development process of chalcones and research progress of 1,3,5-triarylpentane-1,5-diones and 3,5-diarylisoxazoles.Chapter two: Study on the new methods of the synthesis of Michael Addition with chalcones as substrates, copper iodide as catalyst. This method use chalcone as the only substrate, the method is simple, mild conditions and highly yields.Chapter three: Study on the new methods of the synthesis of 3,5-substituted amyl azole with chalcones as substrates, in the condition of metal-free catalyzed and air as the oxidant. This method has the advantage of low-cost, environmental protection, higher yield, and simple post-processing. |
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