Properties Of Aromatic Mothproofiing Sustained-Release Tablets Prepared By Using Eupatorium Adenophorum And Lonicera Japonica Thunb As A Carrier

In this paper, the mothproofing tablets were successfully prepared by the method of direct compression which respectively used eupatorium adenophorum and lonicera powders as a carrier material, aspic volatile oil as flavouring agent and empenthrin as effective constituent. The quality standard and their corresponding analytical methods were investigated and established accordingly, which provided the data for the forthcoming production and registration of the mothproofing tablets. For the mothproofing tablets using lonicera as a carrier material, the formulation conditions and quality criteria of the tablets were investigated, the corresponding trend was obtained.As for the mothproofing tablets using eupatorium powders as a carrier:1、The physical and chemical properties of the crofton weed-based tablets were investigated according to the national standard of p-dichlorobenzene mothproofing agent:at 25℃of ambient temperature under natural light, the properties of the mothproof tablets is:a gray-green cylinder with the smell of lavender,2.033±0.004cm in diameter,0.836±0.002cm in thickness, the density of 1.106g/cm3,34.16 ±0.52N in hardness,0.84% of friability.2、The incorporation method affect the uniformity of empenthrin in the resulting mothproofing tablets. Compared to the method of direct mixing and grinding of empenthrin with adsorbent SiO2, the use of dissolution of empenthrin in acetone and then mixing and grinding of empenthrin with adsorbent SiO2, the tablets obtained from the latter method has better uniformity in empenthrin distribution than the former method, which facilitated the steady release of empenthrin from the tablets.3、The analytical method was established and validated for the active ingredient content of empenthrin in the tablets. The mothproofing tablets was extracted by Soxhlet extractor and Ultrasound methods with acetone, acetone and n-hexane as solvents, respectively. The obtained extract was purified by SPE and then analyzed for empenthrin content by GC. The results of gas chromatogram of the tablets showed that the mothproofing tablets was extracted better by Soxhlet extractor with n-hexane as solvents than the other methods, the recovery of empenthrin was 94%.4、Gas-phase dynamic release experiment was established and used for the investigation of the release of empenthrin from the tablets in vitro. The results obtained from the gravimetric method showed that at 25 C, and the air flow rate of 500ml/min, the release time of 91d, the cumulative amount of empenthrin released reached 30.95%.5、The results of efficacy test showed that the efficacy of the tablets with either the use of lavender, osmanthus and a broad spectrum of flavor as a fragrance agent in the mothproofing tablets can reach grade Ⅱ level, which could devoid the damage to the fabric and met the requirement of national standard of the mothproofing tablet for registration requirements.As for the mothproofing tablets using Lonicera japonica Thunb powders as a carrier:1、The molding pressure was optimized by using the appearance, hardness and friability as the criteria for evaluation. The most appropriate pressure was selected through the friability test and hardness test. The results showed that under the 10MPa the tablets had good appearance, no dregs without leaking of fragrant oil, and the corresponding hardness and friability meet the national standards for mothproofing agents.2、The binder such as hydroxyethyl cellulose (HEC) or polyvinylpyrrolidone (PVP) used in the tablets was optimized by using the appearance, hardness and friability of the tablets as the criteria for evaluation. When using hydroxyethyl cellulose with different viscosity as a binder, the increase in viscosity had no significant effect on the thickness of tablet, but led to the increase in hardness of the tablets, and decrease in friability. Using polyvinylpyrrolidone (PVP) instead of hydroxyethyl cellulose as a binder, resulted in the reduction in the thickness of the tablets, the increase in hardness and friability (but still remain below 1%), in line with the requirements of the national standard;3、Physicochemical nature of the Lonicera japonica Thunb-based mothproofing tabletsAt 25℃ of ambient temperature, under natural light, the properties of the mothproofing tablets using Lonicera japonica Thunb powders as a carrier is:a light green cylinder with the smell of lavender, with a diameter of 2.025±0.005cm, the thickness of 0.794±0.003cm,the density of 1.174g/cm3,the hardness of 55.54±0.98N, the friability of 0.85%.