The Research Of The Synthesis Of 2-aminoimidazoles And The Derivatives

This thesis is focus on the application and synthesis methods of 2-aminoimidazoles and the derivatives, and a high-efficient method using 2-aminopyridines and ?-amino carbonyl compounds as reagents is offered. It mainly consists of three parts as followed.In chapter 1: The overview of the biological activities and pharmaceutical values of 2-aminoimidazoles and the derivativesAs a normal kind of nitrogen heterocyclic compound, 2-aminoimidazoles have received significant attention because of their broad spectrum of biological activities, especially for the antibacterial, antifungal, antiviral, etc. They can also be used as enzyme inhibitor. Moreover, as a result of their remarkable structures, they can be used as fluorescent probes.In chapter 2: developments of the synthesis of 2-aminoimidazoles.The research of the 2-aminoimidazoles started from 1960 s, the Ugi's four-component-reaction should be the most classic method until it was replaced by three-component-reaction. Only a few papers about two-component-reaction can be found. Most of the catalysis systems for the compound are researched detailedlyIn chapter 3: an efficient method for the preparation of 2-aminoimidazoles catalyzed by Lewis acidThe use of the toxic and corrosive reagent in three-component-reaction brings certain limits to the preparation of 2-aminoimidazoles. This chapter provide a concise approach to 2-aminoimidazole via the zinc iodide catalyzed reaction of low-toxic and easily available 2-aminopyridines and ?-amino carbonyl compounds This novel and user-friendly protocol employing diverse and easily available substrates affords the desired products in good to excellent yields. Oxygen is used as the oxidizing agent. This method can be used as a reference for the preparation of 2-aminoimidazoles.