Research On The Synthesis And Application Of 1-indenone Compound

Compounds containing indanone structure has good biological activity,indenoquinoline compounds and indenopyridine.Complexes are widely used in medicine,pesticide science and other fields.Study on the pharmacodynamics of indenone compounds involved in anti allergic,anti cardiovascular sclerosis,anticancer,antibacterial and herbicide etc..In order to expand the indenone compound applied research,this paper improves the synthesis of 1-indenone compound method,and the synthesis of the oxime ester compounds were confirmed,theory and industrial application results are obtained.This thesis mainly select indanone,calixpyrrole and oxime ester compounds of synthetic as the focus of the study,work in the following three aspects:?1?in the laboratory research work on the basis,the work with allyl chloride propionyl chloride and substituted benzene as raw materials synthesized corresponding indanone compounds,study the indanone compounds synthesis and purification conditions;find out have not been reported in the literature AlCl₃-LiCl of molten salt catalysis were still reaction method,the yield can be reached 83.5%,the indanone compounds enlarge the production method is feasible.?2?oxime and oxime ester compounds were synthesized and characterized,the indanone compounds with hydroxylaminhydrochlo-ride as raw materials synthesized the corresponding ketone oxime compounds and has not been reported in the literature of the esterification product oxime ester compounds,oxime compounds yield was up to 80%above,oxime esters compounds yield could reach more than 85%and the related properties were preliminarily.?3?In this work,the synthesis conditions of 2-chloro-1?4-hydroxyphen-yl?ethanone were explored.