| Beta-cyclodextrin(?-CD), a kind of supramolecular materials with excellent biological compatibility, due to its special geometric structure, with the periphery of the hydrophilic and hydrophobic lumen, can form the structure of host-guest inclusion complex with inorganic and organic molecules, won a lot of attention. ?-CD would change the chemical and physical properties of inclusion compound, including preventing guest molecules from being destroyed by the external condition, solubilization guest molecules and improve the stability of molecular characteristics, which provided good properties for the preparation of composite material, were widely used in wound dressing in recent years. In this study, ?-CD was used as additives, company with good biocompatibility of organic material as foundation material, three kinds of drug-loading composite nanofibers were obtained via electrospinning, then the properties and application were studied, the main contents are as follows:(1) Zein/?-CD composite nanomaterial was obtained by electrostatic spinning of Zein and ?-CD in acetic acid system, then the characterization and performance was analyzed. DSC showed that, glass transition temperature of Zein was higher by adding ?-CD. Antifungal drug griseofulvin(GSV) had been loaded into the composite nanofibers by formation of its inclusion complex with ?-CD in acetic acid system to obtain drug-loading nanofibers, and carried on the characterization, differential scanning calorimetry(DSC) for thermal properties of the fiber membrane was studied, the results confirmed the existence of the inclusion structure. Ultraviolet spectrum analysis showed that the final cumulative drug release of drug-loading nanofibers percentage was over 60%, and the early(8 h- 48 h) drug release behavior had slow-release effect.(2) The cellulose acetate/DMAc solution is unable to be electrospun into ultra fine fiber. However, the cellulose acetate(CA)/?-cyclodextrin(?-CD) solution could just be successfully electrospun into uniform nanofibers with different ratios of CA/?-CD. Then the characterization and performance was analyzed. Eventually, antifungal drug griseofulvin(GSV) had been loaded into the composite nanofibers by formation of its inclusion complex with ?-CD. The thermal properties of nanofibers were studied by DSC,the results revealed that the ?-CD-GSV inclusion complex improved the drug's thermal stability. Ultraviolet light(UV-Vis) spectral analysis showed that the final cumulative drug release of drug-loading nanofibers percentage was over 75%, and the early drug release behavior had slow-release effect.(3) Biocompatible polyvinyl alcohol(PVA) –styrylpyridinium(SbQ)/?-cyclodextrin(?-CD) composite nanofibers were obtained by electrospinning in this study. PVA-SbQ was used as the foundation polymer as well as crosslinking agent, ?-CD was incorporated to achieve expected properties such as improved mechanical properties and thermal stability. The Fourier transform infrared spectroscopy(FTIR) spectra confirmed the existence of ?-CD, and the morphologies and average fiber diameters of the electrospun composite nanofibers were also analyzed by SEM. X-ray diffraction patterns(XRD) of PVA-SbQ/?-CD composite nanofibers revealed that the inclusion of ?-CD in the nanofibers affected the ordered phase of PVA. Besides, the thermal analyses revealed the improvement in the thermal properties for PVA-SbQ/?-CD composite nanofibers. It was found that the crosslinked composite nanofibers showed a clear higher tensile strength(TS) as well as a greater elongation at break(EB). Eventually, antifungal drug griseofulvin(GSV) had been loaded into the composite nanofibers by formation of its inclusion complex with ?-CD in aqueous solution, ultraviolet light(UV-Vis) spectral analysis showed that the drug-loading nanofibers had certain sustained release effect, and the cumulative drug release percentage was more than 90%. |
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