Research On Construction Of N-Heterocyclic By Radical Tandem Reaction Of Propargylamine

N-heterocycles as important structural units are widely found in natural products,pesticides,pharmaceuticals and optoelectronic materials,so the construction of N-heterocycles has become an important research in organic chemistry.Free radical tandem reactions have shown outstanding advantages in terms of atomic economy,the highly synthesis efficiency and the friendliness of the environment,which has become an important research topic in the field of organic synthesis.Propargylamine is the synthesis of many N-heterocyclic functional precursors,and it can be synthesized imidazole rings,pyrrole rings,quinoline rings and other functional nitrogen heterocyclic rings.Propargylamine has a wide range of applications in organic synthesis.Its synthesis method is simple,and the reaction conditions are mild,and the preparation of raw materials is easier and it has more reaction sites.In this paper,free radical series reaction is used to construct N-heterocycles.It mainly includes the following two parts:The first part is the reaction of the propynylamine with N-iodosuccinimide.At room temperature,propargylamine with N-iodosuccinimide reaction,methanol as a solvent to produce diiodoquinoline derivatives.The reaction conditions are mild,do not need to add other catalysts,easy to operate,which also provides a new method for the construction of quinoline derivatives.The second part is the reaction of propargylamine with diphenyl disulfide.Also with propargylamine as raw material,and radical tandem reaction with diphenyl disulfide at high temperature provides a new method for directly constructing C-S bond,and maximizes the atomic economy.