Design And Synthesis Of Novel Organic Frameworks Fluorescent Probe

Organic framework materials including metal organic coordination polymer(NCPs),metal organic framework material(MOFs)and covalent organic framework.NCPs are an amorphous coordination polymer formed by the coordination between metal and organic ligands.NCPs have high specific surface area and good thermal stability.In the synthesis of NCPs material will form fixed holes;due to the specificity of organic ligands these holes can have certain recognition of the object molecules.With the concern of NCPs materials,NCPs are increasingly used in fluorescent sensing.The application of fluorescent NCPs improves the sensitivity and detection of detection.As people focus on NCPs materials,NCPs materials widely used in fluorescent sensor.Fluorescent NCPs application improves the detection sensitivity and detection performance.MOFs material is a crystalline frame material formed by metal ions as binding sites with organic ligands.Metal organic framework materials of metal binding sites and the arrangement between organic ligands have very obvious regularity,lead MOFs materials have great gap.The particularity of structure allows MOFs materials reflects a lot of specificity,such as adsorption,electromagnetism and optics.The performance of these special makes MOFs materials did a lot of attention,has become the focus and hotspot in the field of current research in analytical chemistry.In this paper,we synthesized a variety of new MOFs materials by various methods to construct novel proportional fluorescence sensors.COF material is a new type of porous crystal structure formed by covalent bonding.COF materials have many advantages,such as: adjustable,porous and large surface area and other advantages.COF excludes the influence of metal ions relative to MOFs,and covalent bonding makes the COF material more stable.Because of the advantages of this series of COFs materials,it has attracted much attention and has been widely used in gas separation,photoelectrochemistry,catalysis and sensors.Our works are as follows:1.A novel ratio fluorescence sensor for superoxide anion(O2·-)detection was designed with Au nanoparticles-bovine serum albumin(AuNPs-BSA)@terbium/guanosine monophosphate disodium(Tb/GMP)nanoscale coordintation polymers(AuNPs-BSA@Tb/GMP NCPs).The abundant hydroxyl,amino of AuNPs-BSA were acted as binding points for the self-assembly of Tb3+ and GMP to form AuNPs-BSA@Tb/GMP NCPs nanosensor.The obtained probe exhibited the characteristic fluorescence emission of both AuNPs-BSA and Tb/GMP.The AuNPs-BSA not only acted as a template to accelerate the growth of Tb/GMP,but also could be used as the reference fluorescence for the detection of O2·-.The resulted AuNPs-BSA@Tb/GMP NCPs fluoresence probe for the detection of O2·-demonstrated high sensitivity and selectivity with a good linear response range(14 nM-10 ?M)and a low detection limit(4.7 nM).2.The ratio fluorescent nanoscaled MOFs have been found due to the possible applications in sensing.A novel ratio fluorescence sensor for plumbum ion(Pb2+)detection was synthesis with ZIF-8 and rhodamine-B(ZIF-8@rhodamine-B).The nitrogen atom of ZIF-8 were acted as binding points for the self-assembly of rhodamine-B form ZIF-8@rhodamine-B NCPs nanosensor.The obtained probe exhibited the characteristic fluorescence emission of both ZIF-8 and rhodamine-B.The ZIF-8 not only acted as a template to accelerate the rhodamine-B,but also could be used as the reference fluorescence for the detection of Pb2+.The resulted ZIF-8@rhodamine-B NCPs fluorescence probe for the detection of Pb2+demonstrated high sensitivity and selectivity with a good linear response range(15.12 nM-5 ?M)and a low detection limit(5.04 nM).3.A new-stype hexagonally ordered covalent organic frameworks(COFs),COFs has been synthesized by Schiff base condensation reaction between terephthaldehyde and hydrazine hydrate(HHA).COF exhibits a series of advantages,for example high BET surface area and pore volume and strong fluorescence properties.Herein,for the first time,we established a novel ratio fluorescence sensor to detected superoxide radical(O2·-)through COF and rhodamine-B(COF@rhodamine-B).The abundant amino group of COF served as starting points for the spontaneous self-assembling of rhodamine-B.The senor exhibits the characteristic fluorescence emission of COF and rhodamine-B.The fluorescence intensity of COF is unchange as a reference and the fluorescence intensity of rhodamine-B is largely weaken after added O2·-.This ratio fluorescence has good selectivity and sensity to detect O2·-.The ratio of I585/I485 linearly increases with the increasing of O2·-concentration in the range of 11.1 nM-6.0 ?M with a detection limit as low as 3.7 nM.