Rhodium-catalyzed C-H Active Tandem Reactions Of Quinazolines N-oxides With Alkynes

Metal-catalyzed C-H activation has been widely recognized as a step-economic strategy in organic synthesis.Quinazoline scaffold was ubiquitous in many natural products and bioactive molecules,which thus attracted ever-growing attention of synthetic chemists.As a result,the construction of quinazoline and derivatization of quinolines has been an intensive research focus in synthetic chemistry.As one of our interests,our group was intensively focused on quinazoline-based chemistry,including synthetic methodology development and late-stage elaboration of quinazolines and evaluation their bioactive.In this thesis,a new tandem reaction of C-H activation was developed by N-Oxides oriented catalytic.two kinds of new functional heterocyclic molecules were selective synthesized under various conditions.In aqueous solvent,1-[2-(3,4-diaryl-isoquinolin-1-yl)-phenyl]-benzamides were obtained in excellent yields by the reactions of 2,4-diarylquinazoline-N-oxides with alkynes.Under anhydrous condition,2,4-diarylquinazoline-N-oxides reacted with two mole alkynes to selective produce(2,3-Diaryl-inden-1-ylidene)-(1,3,4-triaryll-isoquinolin-8-yl)-amines in one step.