Copper-Promoted Functionaliztion Of C-H Bonds And Synthesis Of Trifluoromethyl Phenanthridines

The transition metal-catalyzed coupling reaction is one of important methods for the formation of carbon-heteroatom bond in organic synthesis. ?-haloalkenyl sulfides, aromatic amines and trifluoromethyl-phenanthridines are important organic structural units. They are widely found in natural products with important biological activities, and are often used in medicine, materials and other fields. In this paper, the synthesis of ?-haloalkenyl sulfides, aromatic amines and trifluoromethylphenanthridines were studied.The dissertation includes four parts:(1) The synthesis of ?-haloalkenyl sulfides, aromatic amines and trifluoromethylphenanthridines were reviewed.(2) The copper-promoted bifunctional synthesis of ?-haloalkenyl sulfides was studied. The three-component one-pot synthesis of?-haloalkenyl sulfide from cheap raw materials, was simple and practical.(3) The copper-catalyzed amination of aryl C-H was developed for the synthesis of aromatic amines with broad substrate scope.(4) The synthesis of trifluoromethylphenanthridines by silver catalyzed cyclization of aryl isocyanide was studied. The reaction was carried out using cheap sodium trifluoromethanesulfinate as the trifluoromethyled reagent and silver nitrate as the catalyst. The reaction conditions were mild and the yields were moderate to excellent.