Synthesis, Characterization And Properties Of Arene-ru( ?) Complexes With Sulf-schiff Bases

Arene-ruthenium(II) complexes are transition metal complexes whose shapes are similar to "tripod piano stool", the coordinate covalent bond between arene and ruthenium is very stable in acid, alkaline,reduction and oxidation conditions, while the coordination bond at other site is easier to be broken, forming new bond with the new ligands . The coordination ability of sulfur-schiff bases are strong and which can coordinate with transition metals to form stable complexes which are usually be used as anti-cancer drug candidate with strong biological activity. According to the law of coordination, four arene-ruthenium(II)complexes with sulfur-schiff bases are designed and synthesized by getting together the arene-ruthenium (II) complex prodrugs and sulfur-schiff bases, and the four complexes are characterized by NMR, IR, EA,TGA as well as X-ray.The interactive mode and intensity between the four complexes and CT-DNA are studied by UV-Vis spectrum in mild acid, neutral and alkalescence conditions and the solution with different pH has been prepared before the test. The experiment phenomena indicate that the complexes interact with CT-DNA by electrostatic interaction. According to the data we obtained three binding constant respectively which showed that the intensity is strongest in neutral condition and weakest in alkalescence conditions. The interactive mode and intensity between the four complexes and ct-DNA is studied by fluorescence spectrum and CV in neutral conditions. The results indicated that the complexes interact with ct-DNA by electrostatic interaction, and the intensity of the sulfur-schiff base containing halogen is stronger than the Schiff base without halogen. Moreover, there is weak adsorption on the surface of the electrode.In this paper, the four arene-ruthenium(II) complexes with sulfur-schiff bases are studied by electrochemistry, UV-Vis, fluorescence and so on. According to the data, the interactive mode and intensity between the four complexes and ct-DNA is obtained which provide the experimental evidence for the design and synthesis of new anti-cancer arene-ruthenium(?) complexes.