Alkynes Coupling And Halogenation Of Quinoline Derivatives

Carbon-carbon bonds and carbon-hetero bonds are important components of organic synthesis chemistry by coupling reactions, and these simple reactions are used to convert simple molecules into complex molecules. Alkynes are important structural units or general intermediates and exist in a number of biologically active molecules and functional materials. Halo gen ated quinoline derivatives are present in natural products with biological and pharmacological activity as well as commercially available drugs. Therefore, the synthesis of these compounds has attracted wide attention. In this paper, the alkyne coupling and quinoline derivatives halogenation reaction are discussed.The paper is divided into the following four parts:(1) A brief review of decarboxylation coupling reaction and terminal alkyne dehydrogenative coupling reaction in recent years; (2) The development of palladium-catalyzed coupling reaction of alkynic acid with allyl ether; (3) Under the catalysis of nickel, the terminal alkyne is coupled with C(sp~2)-H to obtain an alkynylated/cy clized 3-methylene isoindolinone, using N, S-bidentate-oriented; (4) The development of a selective halogenation method for free-metal catalyzed quinoline derivatives. The reaction is simple, green and easy to obtain products.