Study On Organic Reactions Involved In Terminal Alkynes

Terminal alkynes are a very important class of compounds.Good chemical activity makes these compounds widely used in chemistry.They can be used to synthesize ketones,furans,triazoles,pyrazoles and other compounds.Inspired by the need for green and sustainable chemistry,people have been seeking general and practical ways to construct complex molecules while maximizing atom economy and minimizing synthetic steps.O ver the past few decades,considerable progress has been made to fulfill these goals by taking advantage of transition metal catalysis and chemical reagents with diverse and tunable reactivities.Base on that nature of the terminal alkyne itself,1,3-diyne,quinoline,pyrimidine indazole and triazolopyrimidine were synthesized from terminal alkynes in this paper,.Conjugated 1,3-diyne compounds as general components play an important role in the preparation of various functional organic molecules.The magnetic nano copper ferrite with the advantages of large specific surface area,good chemical stability,low toxicity,easy separation,reusability and environmental friendliness is used as a catalyst to promote the coupling reaction of terminal alkynes to synthesize 1,3-diyne compounds.Quinoline compounds are widely used in chemical analysis,dye industry,drug screening and other fields.It is a kind of highly applicable compounds.Therefore,organic synthesis chemists have been concerned about the synthesis of quinoline derivatives.In earlier years,systems for the synthesis of quinoline using transition metals have been reported.However,most of these systems are affected by harsh conditions such as strong acidity or alkalinity,high reaction temperature,etc.In this paper,a green method for one-pot synthesis of quinoline derivatives by using organic metal frame MOF-5 as catalyst is proposed.The target product can be obtain efficiently without solvent.This method is mild,efficient and green.It has important significance for the study of the synthesis method of quinoline derivatives.Ring junction nitrogen heterocyclic compounds are valuable for obtaining biological leads and exploring drug discovery programs.Because these systems exist in several natural and biologically active molecules.They have a variety of biological activities,such as anti-cancer,anti-malaria,anti-hypertension,anti-diabetes,etc.In this paper,pyrimidine indazole derivatives were synthesized by FeCl₃ catalyzed by 3-aminoindazole,aldehyde and alkyne.And triazole derivatives were synthesized by 3-amino-1,2,4-triazole,aldehyde and alkyne under the same conditions.A new synthetic method is provided for the synthesis of cyclic nitrogen heterocyclic compounds.