The Fabrication Of Micro/Nano-textured Titanium Surface With Si-doped And Their Effects On Osteoblasts

Titanium and titanium alloys are widely used in orthopedic surgery due to their excellent mechanical properties,corrosion resistance and good biocompatibility.However,there has one serious post-operative complication because of poor biological activity and bone integration: implant loosen,which can't meet the clinical requirements.The study suggests that the surface morphology and chemical composition of the implant play an important role in the bone integration.Comparing with micro-and nanoscale surface topography,the hybrid micro/nano-textured surface can provide a more suitable surface morphology for osteoblast functions because it can better mimic the natural environment of cell growth.In addition,the chemical composition of the implant surface can also affect the behavior of the osteoblasts by the release of ions or chemical bonding.Therefore,it can effectively improve the bone integration ability of the implant and avoiding the loosening by combining the hybrid micro/nano-textured surface and the bioactive elements.In this study,thehybrid micro/nano-textured titanium surface with different Si-doped is fabricated in containing Ca?NO₃?₂ and different concentration of Na₂SiO₃ electrolytes by micro-arc oxidation.Their structural characteristics,bonding strength,wetting ability,biocompatibility and osteoblast function are evaluated.Based on the work of this paper,the main experimental results are as follows:?1?The hybrid micro/nano-textured titanium surface is fabricated in a containing Ca?NO₃?₂ electrolyte by micro-arc oxidation,which further suggest that NO₃-plays an important role in the formation process of the hybrid micro/nano-textured titanium surface.Comparing with TiO₂ nanotubes fabricated by anodic oxidation,the hybrid micro/nano-textured coating has good bonding strength with the substrate.?2?The hybrid micro/nano-textured titanium surface with Si-doped is fabricated in containing Ca?NO₃?₂ and Na₂ Si O₃ electrolytes by micro-arc oxidation.There is no obvious effect on the formation of micro / nano-composite structure,surface roughness and the pore size of nano-mesopores with adding Na₂ Si O₃.?3?With the increase of Na₂ Si O₃ concentration in the electrolyte,the amount of doping Si is significantly increased.Si element of the coating is evenly distributed in the amorphous TiO₂ oxide layer in form of SiO₂.In addition,the hydrophilicity properties and surface free energy of Si-doped coatings are significantly improved.?4?The hybrid micro/nano-textured coating with Si-doped improved the cell adhesion,spreading,ALP activity,collagen secretion and matrix mineralizationof MC3T3-E1 cells because of its improved hydrophilicity and surface energy and the effect of Si elements in the coating.