Synthesis And Specific Ion Effects Of Backbone Thermal Responsive Hyperbranched Copoly(bis-acrylamide)s

In virtue of the controllable dendritic topological structure and the backbone stimulus response,the backbone thermo-sensitive hyperbranched polymer can load guest molecules such as drugs,catalysts,ions in the form of monomolecular or assembly,and can release the guest molecules or separate from the system together with the guest molecules by using the stimulus response,showing important research value and application prospects.In this paper,hyperbranched copoly(N,N'-methylene bisacrylamide/N,N'-ethyl bisacrylamide)was prepared by RAFT polymerization.The backbone thermo-sensitivity was proved by turbidity analysis.The effects of monomer ratio on the critical phase transition temperature(LCST)of the polymer were discussed.In addition,as a potential drug carrier,the presence of ions in the body may further affect the LCST of HCPAM.Therefore,this paper also studies several common metal ions that affect LCST in HCPAM solution,and the mechanism of ionic effect was proved by infrared spectroscopyThis article is divided into three chapters:In chapter 1: Introduction.The related content of the stimulated response hyperbranched polymer and the specific ion effect of the polymer are briefly introduced,and the design idea and significance of the paper are described in detail.In chapter 2: Preparation,purification and characterization of CTA reagents and monomers,the synthesis and thermo-responsiveness of hyperbranched copoly(N,N'-methylene bisacrylamide/N,N'-ethyl bisacrylamide).In this paper,the phase transition temperature is regulated and the phase transition process is discussed.In chapter 3: This chapter discusses the effect of different ions on the LCST of HCPAM,and gives the corresponding ion sequence,and explains the mechanism of specific ions effects.