Studies On Transition Metal Catalyzed Ortho Alkylation Of Aryl Amides

Use transition metal catalyzed C-H activation has become one of the most effective methods for the C-C bond formation.Due to it has good atom economy and high efficiency,it attracted more attention around the world.C-H alkylation is still a challenge to synthesis nature product and complex molecules.In this thesis,mainly introduced transition metal ortho-alkylation of N-methoxy benzamide and synthesized norbornene derivatives to study it mediate the ortho-alkylation of aryl halide.The contents are as follows:1.We reviewed research progress about transition metal catalyzed C-H para,meta and ortho alkylation of aromatic compound.2.In Chapter 2,introduced norbornene derivative modulated highly mono-selective ortho-C–H activation alkylation reactions on arenes bearing simple mono-dentate coordinating group.Reaction features the employment of readily available benzamides and alkyl halides.During the studies,we have prepared 30 mono-alkylated aryl amides in good yields with good mono-selectivity.We have also demonstrated that structurally rigid alkenes such as norbornene and derivatives are a good class of additives could be used for the future C-H direct functionalizations.3.We synthesized a series of norbornene derivatives according to modify the norbornene structure and changed its physicochemical property.We also use the norbornene derivatives to catalyze the Catellani reaction and found that when use the high steric hindrance it also can control the selectivity of the Catellani reaction.