A Research Of Anti-cancer Properties Based On Multifunctional Core-shell Structure Of Mesoporous Silica Nanoparticles

Mesoporous silica nanoparticles?MSNs?have been extensively considered to be drug carriers with potential clinical application due to the homogeneous morphology,the tunable pore size,high pore volume/surface area,accessible surface functionalization,prominent biocompatibility and degradability.The assembled anticancer drugs consisting with mesoporous silica materials carrier,targeting agent,can achieve good cell or tissue targeting and improve the anti-cancer properties combining with photothermal/photodynamic multiple synergetic means more effectively.So this topic chose the multifunctional nanocomposites based on mSiO₂ core-shell structure as the research object,further studied its synthetic route,drug release properties,photothermal properties?PTT?and photodynamic therapy?PDT?performance,for the realization practical application of the mesoporous materials as controlled release drug carriers provides experimental basis.The main contents follows three aspects:?1?A magnetic drug delivery system was constructed by using core-shell mesoporous silica nanocomposite?Fe₃O₄@m SiO₂?as carrier.Then hydrochloric acid doxorubicin?DOX?as a model drug could be loaded into the mesoporous channel through electrostatic attraction.By a simple silane coupling reaction,a GSH cleavable diselenide compound?-Se-Se-linker?has been prepared and grafted on to Fe₃O₄@mSiO₂ to insure the encapsulation of DOX.The detail release kinetics studies revealed GSH could trigger drug release,and the kinetics could be adjusted by varying the amount of-Se-Se-linker.After modified with folic acid?FA?,the targeted drug release system with enzyme-responsive was constructed successfully.?2?Cu₉S₅@mSiO₂-ICG-PEG-LA with good dispersion,stability,targeting property was designed.The material was consisted with core-shell mesoporous silica nanocomposite?Cu₉S₅@mSiO₂?carrier,loaded photosensitizer indocyanine green?ICG?,modified with polyethylene glycol?PEG?and lactobionic acid.Under 808 nm near infrared irradiation,photothermal properties?PTT?of Cu₉S₅ and ICG,and reactive oxygen molecules generating from photodynamic performance?PDT?of ICG would improve the cytotoxicity to cancer cells.The structure of the system was characterized.Cell experiments used to prove its quickly uptaken and cytotoxicity.?3?A photo and redox-responsive nanocomposite for drug delivery based on anti-cancer drug doxorubicin?DOX?loaded,photosensitizer indocyanine green?ICG?conjugated,redox-responsive-Se-Se-linker blocked,folic acid?FA?targeted,silica-coated gold nanorods?FA-GNRs@m SiO₂-ICG-DOX@Se-Se?was strategically designed.Upon redox-responsive environment,GSH could cleave-Se-Se-linker triggering drug release.What's more,upon the irradiation with a 808 nm laser,the photo activated PDT and PTT could also initiate and accelerate drug release.The novel multifunctional drug release system combined chemotherapy and PDT/PTT will provides data for the clinical application based on multifunctional anticancer drugs.