Design And Preparation Of Photonic Crystals For SALDI Enhancement

Surface assisted laser desorption ionization is a kind of matrix free laser desorption ionization method,which is of great significance to the development of mass spectrometry.SALDI uses the nano materials to absorb laser energy,indirectly transfer the energy to the analyte to desorption ionization.It protects the analyte from direct laser damage and reduces analyte fragmentation.SALDI has been developing rapidly in recent years because of its huge potential of application,and its substrate material is still a hot topic.In addition to the chemical properties of the material itself,the special photoelectric properties produced by its unique physical structure provide a new idea for the research of the SALDI substrate.Photonic crystals is an artificial media with with periodic distribution of refractive index,with excellent ability to control photons,have great potential applications in the fields of optics and electricity.Photonic crystal's most fundamental feature is the photonic band gap,the light in the band gap will not spread.At the high and low energy boundaries of photonic crystals,the light exists in the presence of a standing wave commensurate with the photonic lattice and travels at a group velocity close to zero,which is known as "slow photon".Photonic crystals have the ability of zero velocity slow light in theory,which can greatly increase the interaction time between laser and nanomaterials.In this paper,we discuss the method of photonic crystal enhanced SALDI,and according to the properties of semiconductor metal oxide and the bandgap properties of photonic crystals,we designed inverse opal photonic crystals with analytic laser wavelength and slow light effect.The enhanced laser desorption ionization substrate based on tungsten and titanium oxide was successfully prepared and the method of preparing the photonic crystal substrate doped with carbon quantum dots,gold nanoparticles and detonators is further explored.The main research contents of this paper are:(a)Design and preparation of metal oxide semiconductor bandgap inverse opal photonic crystals(the second chapter):selection of tungsten titanium oxide as substrate material,designed and prepared the inverse opal photonic crystal of slow light in different spectral regions.(b)Tungsten titanium oxide inverse opal photonic crystal doped design and preparation(the third chapter):to enhance the ability of metal oxide semiconductor inverse opal photonic crystal on the optical absorption of semiconductor quantum dots by doping noble metal nanoparticles and the way.Design and fabrication of tungsten titanium oxide inverse opal photonic crystals doped with carbon quantum dots and aurum nanoparticles.(c)The design and preparation of the tungsten-titanium oxide inverse opal photonic crystal with the detonating agent(Chapter 4):The nanostructure detonator can promote the desorption ionization of the mass spectrometer.The design and preparation of the tungsten titanium oxide inverse opal photon crystal.(d)enhanced laser desorption ionization effect of tungsten titanium oxide inverse opal photonic crystal(the fifth chapter):preparation of tungsten-titanium oxide inverse opal photonic crystals with different band gaps in the spectrum was used as a substrate for mass spectrometry,and the sample with laser wavelength coupled to slow light effect is the best to enhance the desorption ionization.