Preparation Of Hollow Mesoporous Bioactive Glass Drug Delivery System And Bionic Fibrous Scaffold

The traditional way of drug intake can change the concentration of blood drug in the body.,the effective utilization rate of drugs in the body is low.it is difficult to give full play to the effect in the process of treatment.It is an urgent issue to prepare new drug carrier to realize the release of drug molecule.The hollow mesoporous bioactive glasses?HMBG?has good biological activity,biocompatibility,pore size adjustable,active site and large specific surface area,has a good ability of drug storage and slow release.Silk fibroin?SF?is a natural high molecular fiber protein derived from silk,which has the properties of breathability and oxygenation,slow release and excellent biological properties.It is an ideal material for drug carrier.To achieve drug loading and release,increase drug stability and effective utilization,in this article,from the perspective of the suitable for drug carrier material,choose HMBG as drug carier,through the SF and HMBG organic/inorganic compound,preparation of new type of the drug loading SF/HMBG composite material.Specific research contents are as follows:?1?Synthesis and properties of the hollow mesoporous nanospherical bioactive glasses.The hollow mesoporous nanospherical bioactive glasses were conducted though sol-gel method via using cetyltrimethylammonium bromide?CTAB?as the soft template.The surface morphology,particle and cavity size of the hollow mesoporous nanospherical bioactive glasses were controlled via adjusting the addition of cetyltrimethylammonium bromide.The surface morphology,internal structure,dispersion state and composition of the hollow mesoporous nanospherical bioactive glasses were determined using TEM,FE-SEM,EDS,XRD,FT-IR and N₂ adsorption-desorption,etc.The results showed that the morphology,structure,particle size and specific surface area of the hollow mesoporous nanospherical bioactive glasses can be adjusted or tailored by the different incorporation of CTAB.These samples exhibited very high specific surface area and adjustable pore diameter which may have potential applications in the field of drug delivery and release.?2?Synthesis and properties of the hollow mesoporous nanospherical bioactive glasses for drug release and bioactivity.Selection the hydrophilic drugs?vanncomycin hydrochloride?and hydrophobic?dexamethasone?as a model drug molecules,in terms of different pH vanlues?pH=4.5,7.4?,the study in controlled drug release of different particle sizes of HMBG was studied.The ability of hydroxyapatite was observed and the bioactivity of the hydroxyapatite was studied.The ability of induce hydroxyapatite was studied via bioactivity in vitro.The results showed that the higher surface areaand porosity of the sample,the better the drug loading and release effect.In the release medium of different pH vanlue,the drug release effect is different,and the drug carrier has a certain pH sensitivity.And the HMBG materials can induced hydroxyapatite formation and had good bioactivity.?3?Fabrication and characterization of the drug loading SF/PEO/HMBG composite materials for bioactivity.With silk fibroin?SF?as an organic part of the stent materials,the drug loading HMBG as inorganic material,the drug loading SF/PEO/HMBG composite materials was prepared by electrospinning.The surface morphology and composition of the drug loading SF/PEO/HMBG composite materials were distinguished by FE-SEM,EDS,FT-IR and XRD etc..The ability of induce hydroxyapatite was studied via bioactivity in vitro.We found that the preparation of the drug loading SF/PEO/HMBG composite materials had fiber morphology,the surface was smooth,reticular structure,had a certain gap between fiber,and had the ability to induce the formation of hydroxyapatite,had good bioactivity.In conclusion,the drug loading SF/PEO/HMBG composite materials were excellent drug control-released carrier with biological activity,and has potential as a drug delivery material applied in the biomedical sciences.