Study On In-situ SERS Detection Of Surface Chemical Residues Using Flexible And Transparent Metal Metamaterial

Surface-enhanced Raman scattering(SERS)technology as an important tool for identifying the structure of material has been widely used in life sciences,food sciences,materials sciences,archaeology,agriculture and other research fields.As the core factor affecting the strength of SERS,the preparation of SERS-active substrate has always been the main task of scientific researchers.In view of the fact that the current SERS-active substrate is difficult to achieve in-situ detection of real samples due to its poor optical transparency in practical detection applications,a flexible and transparent SERS-active metal metamaterial(FTSM)preparation method is proposed.A comprehensive evaluation was made of its structural parameters and performance indicators,and a detailed examination of its effect on the in-situ detection of chemical residues on the surface of material was conducted.In this paper,a high-performance SERS-active substrate has been prepared by a fast and efficient liquid/liquid interface self-assembly(LLI)method.And then a flexible and transparent substrate has been combined to improve the applicability of the substrate.The prepared FTSM exhibits excellent optical properties with an optical transparency of over 90%.The Raman detection results shows the enhancement factor of the substrate is 10-6-107 approximately,the relative standard deviation of SERS signal is less than 10%,and the substrate shows good stability.At the same time,FTSM can be applied to in-situ detection on the surface of different roughness materials with good flexibility.This article explores the application of FTSM in the real-life detection.Through the use of FTSM for the detection of mitoxantrone,lidocaine,methotrexate and other drug molecules,it was confirmed to have high sensitivity,specificity,and suitable for quantitative analysis;The analysis of real sweat sample confirmed its suitability for mixing analysis of component samples;Through the detection of residual traces of chemical molecules on the surface of irregular glass tubes,it was confirmed that the substrate was able to realize the in-situ detection on the surface molecules of the samples to be tested,and further research proved that it has good flexibility and transparency,and the fabrication of FTSM provides new ideas for SERS technology in actual field analysis.In addition,this article has also developed a fast Raman imaging application based on FTSM.Its imaging speed is 1000 times faster than traditional Raman imaging.The imaging of the complex surface of fingerprints and other real samples proves that the FTSM-based SERS imaging can reduce the complex topography of the sample to be tested and has high accuracy.At the same time,fitting the SERS imaging with the least squares method can be used to determine the order of superposition of imaging molecules.These research results provide new ideas for trace analysis,chemical imaging and other areas of research.