Synthesis Of Biphenyl Salicyloyl Schiff Base Fluorescence Probes And 8,8??-dimethoxycupressuflavone

Schiff bases,whose structures contain a unique imine group(HC=N)or an azomethine group(RC=N)can combine with different organic groups to show different properties,making this class the degree of concern for compounds in many areas is constantly increasing.Some of these compounds are good ligands that can form complexes with many metal ions.After the coordination with the target metal ions,the mother liquid to be tested will undergo a significant color change or a change in its own absorption spectrum,so as to detect and quantitatively analyze the content of metal ions in the mixture.Synthesizing fluorescent probes from Schiff base and its derivatives is of great significance in the detection and monitoring of heavy metal pollution in the natural environment.Biphenyl compounds are the constituent structures of many organic synthesis intermediates and natural products and have many activities themselves.Hydrazide Schiff base is a Schiff base derivative,has a strong chelating ability and a variety of coordination modes,and its unique active substructure-CONHN=CH-group,has a very good fat-soluble And cell permeability.Combining the advantages of the two,in this paper biphenyl was used as the parent,Two new biphenyl salicylhydrazone Schiff base fluorescent probes and natural product 8,8??-dimethoxycupressuflavone were synthesized.In chapter one,the article summarizes the development of biphenyl-based compound ion fluorescent probes,hydrazide ion fluorescent probes,and salicyl hydrazide ion fluorescent probes,and puts forward the research contents and ideas of this paper.In chapter two,the biphenyl salicyloyl hydrazide Schiff base fluorescent probe L1 was designed and synthesized,and its structure was characterized.The optical properties and applications of the compound were also investigated.In chapter three,the biphenyl salicylhydrazone Schiff base fluorescent probe L2 was designed and synthesized.The optical properties of the biphenyl salicylhydrazone Schiff base fluorescent probe L2 were investigated.The recognition of Cu2+ was highly sensitive and the fluorescence quenching probe was used.In chapter four,8,8??-dimethoxycupressuflavone is based on biphenyl as a skeleton,and has a wide range of pharmacological effects,such as a class of biflavonoids such as antiviral,antioxidation,expansion of peripheral blood vessels,elimination of free radicals and antitumor properties.Some scientists have extracted from the plant Zabelia tyaihyonii,but the use of chemical synthesis of the biflavonoid has not been reported so far.This paper selects vanillin and 2,4,6-trihydroxyacetophenone as the starting reactants,protected by hydroxyl groups.Oxidative coupling of C-C,oxidation of aldol,condensation within the molecule,deprotection and other steps to synthesize the target compound 8,8??-dimethoxycupressuflavone.