Aminofluorination Of Styrenes And Cycloaddition Of Alderhyde Hydrozone Reactions Via Visible-light Photocatalysis

Radical chemistry has been widely concerned by chemical workers for its unique properties.The vigorous development of radical chemistry also provides an opportunity for the revival of photochemistry.In particular,photoredox catalysis is widely used in organic synthesis because of its advantages such as mild conditions,environmental friendly and so on.Nitrogen-centered radicals play a crucial role in many chemical and biological processes.Therefore,the methods that generate stable nitrogen-radicals efficiently and apply it to organic synthesis are hot topics in radical chemistry.This dissertation is divided into three chapters,which describes in detail the visible-light-induced nitrogen-radical formation in organic synthesis.Part I:This chapter first summarizes the research and development of nitrogen-radicals produced by traditional methods.Secondly,the development of visible light catalysis and visible-light-induced nitrogen-radicals formation was described in recent years.Part II:?-fluoroamines are widely distributed in the structure of natural products and drug molecules.In this chapter,we first describes the progress in the synthesis of ?-fluoroamines.Then,we have developed a visible-light mediated radical bifunctional reaction of styrenes and successfully synthesized ?-fluoroamines.Employing the shelf-stable N-Ts-potected 1-aminopyridium salt as nitrogen-radicals precursor and commercially available hydrogen fluoride-pyridine(Olah's reagent)as nucleophilic fluorine source,We successfully synthesized the target molecule by visible light catalysis.Part III: This chapter first introduced the research progress of radical reaction of organic azide compounds in organic synthesis,and then introduced the research progress of benzaldehyde oxime as a substrate in radical reactions.On this basis,employing the Zndankin reagent as a source of azide-radicals and benzaldehyde oxime as a substrate to synthesize a tetrazole compound by visible light catalyzed [3+2] cyclization reaction.