Mechanics Analysis & Experimental Research On Needle-free Micro-jet Injection

The needle-free micro-jet injection is widely used, more and more scholars and clinicians focused on its researches. According to large numbers of literatures and experimental researches, there are four problems. In general, these researches are lacking in three model researches and a product development. In detail, an engineering model research should be done to describe the performance and characteristics, an engineering model research should be done to express the effect and its influencing factors of skin puncture, an engineering model research should be done to analyze the liquid penetration under the skin after injection and a micro-jet injection should be developed to achieve continuous injection. So a continuous micro-jet injection powered by voice coil motor (VCM) was designed in this paper. And its mechanical structure and working principle was introduced to describe the performance and characteristics, its skin puncture was researched to express the effect and its influencing factors of the injection, the liquid penetration under the skin after injection is researched to fill the blank of these researches.This paper contains five chapters. In the first chapter, the background and significance of this research is introduced, and the content and target of this paper is put forward. In the second chapter, the structure and control system of the continuous needle-free injection is introduced. In the third chapter, the engineering model of the drive system and injection system of the continuous micro-jet injection is researched. An electromagnetic numerical analysis model based on the VCM and the dynamic model of high speed jet are built and calculated by MATLAB. The hypothesis of the variable-doses continuous injection is put forward and verified. In addition, a pressure testing experiment for jet had been done to compare with the calculation results from MATLAB and verify the accuracy of the engineering model. In the fourth chapter, the skin biopsy model, liquid expansion model and the liquid penetrant model of the continuous micro-jet injection was researched and verified by the simulation of Fluent. At last, the main content and innovations of this paper is emphasized and the problems existing and the prospect of this research is pointed out.