1 The Pharmaceutical Study On A Kind Of Orally Disintegrating Tablet For Pets 2 The Study On Dissolution Of Polysaccharide Iron Capsules

In recent years,the number of pets(dogs and cats)raised increased year by year,with the increase in the demand for drugs.At present,the contraceptives for pets are those which mainly contain single ingredient.The project aimed to develop a kind of compound oral disintegrating tablet(ODT),which can be used as contraceptive and sedative.But the ODT was mainly used as a contraceptive for pets.Firstly,we determined megestrol acetate and phenobarbital as main ingredients.The megestrol acetate played as contraceptive and phenobaribital played as sedative.The specifications of megestrol acetate and phenobaribital were 20.1mg and 9.9 mg,respectively.Secondly,we determined the type and dosage of excipients by the single factor test and orthogonal test.We got the final prescription.prescription Ratio(%)megestrol acetate 6.7 phenobarbital 3.3 mannitol 46.3 MCC 35 L-HPC 8 aerosil 0.2 magnesium stearate 0.5 total 100Thirdly,we selected high performance liquid chromatography as the analytical method for the main ingredients and studied its methodological validation,The results suggested that the analytical method was reliable and accurate,and able to meet the analysis requests.Lastly,we prepared three batches of tablets and studied their quality.The results suggested the ODT was white or almost white and smooth sheet,its friability and hardness could be up to standard,and the content and content uniformity of main ingredients meet the requirement.The dissolution of the two main drugs within the allotted time was greater than 75%,all the quality of the ODT could meet the requirement of Pharmacopoeia.Iron deficiency anemia(IDA)is caused by the inadequate intake of iron,it is a serious problem related to nutrition worldwide and it is also a disease which badly does harm to human health.So far,iron supplement is the main product to treat this disease,this product include two types,inorganic iron and organic iron.Among them,polysaccharide-iron,which is deemed as an ideal iron supplement taken orally has advantages of mild irritation and high bioavailability.So it has become the hotspot of researchers both here and abroad.We mainly studied the dissolution of imported polysaccharide iron complex capsules(Niferex)in this paper.Firstly,we established a method of phenanthroline spectrophotometry to determine the dissoiution liquid,and verified the method.The results showed that the concentration of iron in the range of 0.2 to 4.0 ?g per ml,the concentration of iron and absorbance values were in good linearity,the average recovery was 99.03 % and the RSD was 0.73 %.Therefore,the method was accurate and reliable,and it was appropriate to determine the iron in the dissolution liquid of polysaccharide iron capsules.Then,we established a method of dissolution for polysaccharide iron complex capsules(Niferex),and determined the speed and dissolution agent.We compared the dissolution of polysaccharide iron complex capsules in four different kinds of agent,and also compared the dissolution of different batches of polysaccharide iron complex capsules in the same agent.The results showed that the dissolution of polysaccharide iron complex capsules in different agent was more different than the different batches of polysaccharide iron complex capsules in the same agent.