The Expression Levels Of Serum VEGF In The Diabetic Nephropathy And The Correlation Study Between VEGF And Microalbuminuria

Objective To explore the changes in the expression levels of serum VEGF and the relationship between VEGF and microalbuminuria in the DN.Methods We selected 54 cases of diabetes with or without albuminuria and divided them into three groups according the 24 h urine albumin quantitative: non albuminuria group, microalbuminuria group, and macroalbuminuria group. We also selected 20 cases of healthy outpatients as control group. We used ELISA method to detect the levels of serum VEGF in different group, and at the same time, collected the clinical indicators such as fasting blood glucose,serum creatinine,urea nitrogen,glycosylated protein,systolic and diastolic blood pressure and so on. The data were analyzed with SPSS 17.0.Results First, the serum VEGF levels significantly increased in the micro and macroalbuminuria groups comparing with control group,(both P<0.05),while the nonalbuminuria group showed an increasing tendency(P = 0.63>0.05);second, compared with the nonalbuminuria group, serum VEGF level was significantly increased in macroalbuminuria group(P<0.05), while the microalbuminuria group showed an increasing tendency(P = 0.077>0.05); third, the serum VEGF level was significantly correlated with fasting blood glucose(r = 0.629, P <0.01) and urine microalbumin(r = 0.377, P <0.01),but not with duration of DN, serum creatinine, urea nitrogen, uric acid, glycated protein, C-reactive protein, systolic and diastolic blood pressure.Conclusion The serum VEGF level significantly increased in diabetic patients,and the correlation between the VEGF level and microalbuminuria was positive; it may be an important means of prevention and treatment of proteinuia in DN that inhibits the excessive expression of VEGF.