Therapeutic Approach To Alzheimer's Disease By Cholesterol

There are several hypotheses about the potential etiological factor and pathogenesis of Alzheimer's disease (AD). Among them, amyloid precursor protein (APP) metabolic desorder, beta-amyloid protein (a-beta) as the core of senile plaque abnormal deposition are widely accepted in the academic world. In 1994,sparks[1] reported intakes of high cholesterol diet would increase the A? deposits in brain tissue of rabbits.Research over the past two decades provided a mechanistic link between cholesterol and AD pathogenesis. Altered neuronal membrane cholesterol level and/or subcellular distribution have been implicated in aberrant formation, aggregation, toxicity, and degradation of A ?-related peptides. Based on epidemiological and basic medical research suggests high cholesterol is associated with AD, people started a wide range of drug study,particularly Statins to reduce cholesterol and on the efficacy of AD. This article will provide an Review of the above-mentioned content.