Prevalence Of Hyperuricemia Among Adult Yi Rural Residents In Liangshan Region

Objective: To investigate the levels of serum uric acid and prevalence rate ofhyperuricemia(HUA)and other metabolic diseases among Yi rural residents in Liangshan Yi Automomous Prefecture(Liangshan)of Sichuan province;to explore predictive value of obesity and relevant metabolism indexes for hyperuricemia;soto provide epidemiological evidencesfor dietary interventions and guidance for further prevention and control of HUA.Methods: Stratified random cluster sampling was adoped to select 972 permanent residents aged ? 18 years in Liangshan for a cross-sectional study.Participants' demographic characteristics,health-related behaviors and dietary behaviors were obtained.Height,weight,blood pressure,waist circumference and hip circumference were measured.Venousblood samples were taken from each subjects for measurements of blood biochemicalparameters included fasting plasma glucose(FPG),blood fat(TC,TG,LDL-C,HDL-C)and the serum urid acid(SUA).The collected data were analyzed by using SPSS 23.0(statistical package for social sciences).Two-independent-samples t testwere used for comparision of mean level of serum uricacid among different groups.Chi-square test was used for comparision of prevalence ofHUA among different groups.Chi-square trend test was used for the trend analysis ofprevalence of HUA.Single-variable and multi-variables logistic regression analysis were used toexplore risk factors of HUA.Spearman correlation was used to analyze the relationship between HUA and obesity indexes and receiver operating characteristic(ROC)curve was used to determine the best predictable value of HUA with maximum Gordon's index as the best cut-off point.Results:(1)The prevalence rate of HUA in the population was 22.0%,30.4% inmen and 12.3% in women;there was a significant gender difference in HUA prevalence rate among the participants(?2=105.429,P=0.001).(2)There were significant age-differences in hyperuricemia group and normal group in male.Body mass index(BMI),waist circumference(WC),hip circumference(HC),waist-to-hip ratio(WHR),waist-to-height ratio(WHtR),systolic pressure,diastolic pressure,TG were significant higer than normal group in male;the body mass index(BMI),waist circumference(WC),hip circumference(HC),waist-to-height ratio(WHtR),total cholesterol(TC),and low density lipoprotein(LDL-C)were significant higer than normal group in female.(3)Life styles have different effects on the levels of serum uric acid and theprevalence rate of HUA.There was an increasing trend of the prevalence rate of HUA and level of SUA,with the increasing frequency of smoking and drinking(P<0.01).There was decreasing trend of the prevalence rate of HUA,with the increasing frequency of effective numbers of exercise(P<0.01).But,prevalence bedtime snacks,regular having hot pot and barbecue,the higer of uric acid and hyperuricemia(P < 0.01).(4)Hyperuricemia group concomitant with hyperlipidemia,high TG hyperlipidemia,high TC levels,high LDL-C hypertriglyceridemia,low HDL-C hyperlipidemia,hypertension prevalence rates were significantly higher than normal uric acid group(P <0.01).(5)Multi-variate Logistic regression models indicated that,male(OR=2.221,95%CI1.433~3.419),overweight(OR=1.624,95%CI1.055~2.489),obesity(OR=2.566,95%CI1.252~5.261),hypertension(OR=1.921,95%CI1.205~3.063),hepertriglyceridemia(OR=2.353,95%CI1.471~3.765)were associate with increased risk of HUA.(6)Spearman correlation analyses showed that SUA was positively correlated with BMI,WC,HC,WHR,WHtR,and triglyceride(TG)(all P<0.01)but reversely correlated with high density lipoprotein(HDL-C)(r=-0.132,P=0.005)among the male participants;whereas among the female participants,SUA was positively correlated with BMI,WC,HC,WHR,WHtR,TC,TG and LDL-C(all P<0.01)but reversely correlated with high density lipoprotein(HDL-C)(r=-0.115,P=0.009).The highest area under the ROC curve of BMI for BMI for HUA diagnosis was 0.635,with a cut-point of 23.0kg/m2,for the male participants and that of HC for HUA diagnosis was 0.605,with a cut-point of 87.5cm,for the female participants.Conclusions The levels of serum uric acid in the population of Yi residents was high,and the prevalence rate of HUA and obesity are high.Obesity and relevant metabolic indexes are of predicative significance of HUA among adult Yi rural residents in Liangshan region.The main influencing factor is the bad habits of lifestyle.Greatly improvements in work of health education aim directly at balanced diet as well as good lifestyle will proved to be significant in the prevention of HUA in the population of Yi residents.