A Meta Analysis Of The Treatment Of Bronchial Asthma Patients Based On Their Sputum Eosinophil Count

Background:The severity and control level of asthma can be measured by subjective and objective measurements. The percentage of sputum eosinophils is the direct measurement of airway inflammation by sputum analysis.It is a method of objective monitoring of asthma. The traditional way of treatment and management of asthma is based on the symptoms and spirometry. But, what is the different outcome between them Objectives Using the method of Meta-analysis, we evaluate the comparison of asthma control effects based on the percentage of eosinophils (EOS) in induced sputum and on symptoms and pulmonary functions which are used traditionally. Methods:Using computer and manual searches (English literature search:the PubMed, EMBASE and Cochrane library; Chinese literature search:the cnki, Wanfang and VIP databases), all data is collected from clinical comparative studies that compared the outcomes of therapies based on eosinophils (EOS) count in induced sputum and on symptoms and pulmonary function. Using the "risk of bias" assessment tool which the Cochrane Collaboration provides and improved Jadad scale, to access the quality of selected articles. Setting up data extraction from extracting documented data using Cochrane Collaboration Review Manager 5.3 software, literature was tested for heterogeneity, then making the forest plot, merging the statistical parameters. Results Finally, six studies were included in the analysis (a total of 353 subjects, of which 312subjects completed the trial). Meta analysis shows that, compared to the traditional therapy based on clinical symptoms, therapy based on induced sputum eosi nophi I count can effectively reduce the frequency of asthma exacerbations However, there is no statistical difference of the treatment effects between the two groups,, such as dai ly average usages of inhaled corticosteroids, daily symptom soores. And both of the two groups had no adverse events repoted. It’s reported i n the literature that sputum induction can not always be successful. Conclusions: This meta analysis shows that, compared to the traditional therapy based on clinical symptoms, therapy based on induced sputum eosi nophi I count can effectively reduce the frequency of asthma exacerbations. It also supports the use of indused sputum eosi nophi Is i n adults who have a frequent episodes of asthma and in severe asthma.