The Changes And Significance Of Inflammatory Cells In Induced Sputum In Asthmatic Children In Different Period

ObjectiveTo investigate the changes and significance of inflammatory cells in bronchialinduced sputum in the same children with bronchial asthma in different period.MethodsIn children with bronchial asthma and normal volunteers by way of hypertonicsaline inhalation challenge, 24 patients in the acute exacerbation of asthma, take 12 ofthem induced by infection as infection team, the lest was uninfection team. thebronchial induced sputum was taken per month after inhaled glucocorticoids. Inducedsputum was also taken from 12 healthy children as the controls.Results1, In acute exacerbation of asthma Eosinophils increased significantly in infectionand uninfection teams compared with healthy controls (p＜0.05), Eosinophils leves inuninfection teams were higher than infection team(p＜0.05), neutrophils decreasedsignificantly in infection teams than uninfection teams and healthy controls (p＜0.05).2,neutrophils and Eosinophils leves in brochial induced sputum were increased ininfection team after treatment, Eosinophils leves in uninfection team increasedsignificantly.ConclusionBronchial asthma is a chronic airway inflammatory disease. There are differentialcell counts in bronchial induced sputum in different stages. Infection result in highlevel of neutrophilsand uninfection result in high level of Eosinophils. Both of themhave changes after systemic treatment.