The Efficacy Of Paroxetine Combined With The Low Frequency Repetitive Transcranial Magnetic Stimulation In Treating Depression With Anxiety

BackgroundDepression is clinically a common mental disorder, with a significant and long-lasting low depression mood, and a high recurrence rate. In clinical work, a large amount of depressive patients usually have anxious symptoms, and the coexist of depression and anxiety severelly affects their life.It’s necessary for the clinicians to explore a safe and effective method to treat these symptoms.Methods to treat the disease of depression and anxiety in clinic usually includ drug treatment, psychological treatment and modified electric convulsive therapy, and so on. However, researches of paroxetine combined with the the low frequency rTMS in treating depression with anxiety symptoms is really rare. ObjectiveTo explore the clinical efficacy and safety of paroxetine combined with the lowfrequency rTMS in treating depression with anxiety symptoms. Methods90 depressive patients with anxiety symptoms were enrolled in this research andrandomly divided into three groups-A group, B group and C group. The patients in group A were treated with paroxetine combined with the rTMS. The patients in group B were treated with paroxetine combined with the pseudo rTMS, and the patients in group C were treated with paroxetine only.The dosage of paroxetine in three groups was 20mg per day, and the rTMS was last 5 days per week. HAMD, HAMA, CGI were used to evaluate the therapeutic effectiveness of the three groups at the baseline and after 1,2,4,6 weeks of treatment. The side effects were recorded during the 6-weeks’treatment, and TESS was used to evaluate the therapeutic safety of the three groups. The collected data were analyzed by the SPSS 19.0 statistical software.Results1.Effectiveness evaluation results: ①After 1-week and 2-week treatment, the HAMD, HAMA scores of three groups were lower than the baseline scores, but the difference among the three groups was not statistically significant (p>0.05); The CGI-EI score in group A was higher than that in group B and C, and the difference among three groups was statistically significant (p<0.05);②After 4-week treatment, the differences of the HAMD and HAMA scores among the three groups were statistically significant (p<0.05);The CGI-EI score in group A was higher than that in group B and C, but the difference among three groups was not statistically significant (p>0.05);③After 6-week treatment, the differences of the HAMD and HAMA scores among the three groups were statistically significant (p<0.05);The CGI-EI score in group A was higher than that in group B and C, and the difference among three groups was statistically significant (p<0.05);④After six weeks of treatment, the effective rate was 89.3% in group A,75.9% in group B, and 75.0% in group C, and the difference among three groups was not statistically significant (p>0.05)2. Safety evaluation results:there were no obvious abnormalities of laboratory parameters among the three groups of patients during treatment, and no differences were found in. The side effects were such as nausea, dry mouth, headache, tinnitus, dizziness, constipation, abnormal liver function, weight gain and abnormal electrokardiagram. These side effects were relatively mild. The differences of three groups in the incidence of side effects were not statistically significant (p>0.05).Conclusion1. Paroxetine combined with the low frequency rTMS in the treatment of depression with anxiety symptom took curative effect faster, and its efficacy was certain.2. The treatment of Paroxetine combined with the low frequency rTMS in depression with anxiety symptoms was safe, with patiens of good tolerance.