Clinical Curative Effect On Treatment Of Lung Qi Deficiency Syndrome Of The Stable Phase COPD Patients By Lijinfang

Objective:To observe the clinical curative effect,Chinese medicine symptom score,pulmonary functionand the level changes of interleukin-17（IL-17）and transforming growth factor-beta1（TGF-β₁）in serum before and after treatment of Lijifang in treating the pations with chronic obstructive pulmonary disease（COPD）in stable phase with lung qi deficiency syndrome,discusses the influence of lijinfang for curative effect in the stable phase COPD patients with lung qi deficiency and its mechanism about inhibiting the airway inflammation and delaying the airway remodeling.Methods: According to random number table method,divided the 60 patients who met the standard of COPD stabilization lung qi deficiency syndrome into control group and treatment group,each group had 30 cases.The control group given the basic treatment of Western medicine,that is,thiamethoxam bromide powder inhaler inhalation therapy,one at a time,once a day.Treatment group given lijinfang on the basic of the control group,100 ml each bag,one bag at a time,two times a day.After two months of treatment,we observed the clinical curative effect,Chinese medicine symptom score,pulmonary ventilation functionand the level of IL-17 and TGF-β₁ in serum.Results:（1）Comparision of the curative effect:the total effectiveness of the treatment group was 93.3%,the control group was 76.6%,the treatment group was better than control group（P<0.05）.（2）Comparison of Chinese medicine symptom score:the treatment group obviously improved the symptoms of patients,as cough,wheezing,expectoration,shortness of breath,spontaneous sweating,exhaustion（P<0.05）,while the control group only improved the symptoms of cough,wheezing（P<0.05）;Comparison between two groups,the treatment group was significantly better than the control group on Chinese medicine symptom score（P<0.05）.（3）Comparision of pulmonary ventilation function:The treatment group effectively improved the forced expiratory volume in one second（FEV₁）,but it did not improved the first second forced expiratory volume of orced vital capacity percentage（FEV₁/FVC%）,the control group of also could imprved FEV₁,FEV₁/FVC% had been not imprved.Comparison between two groups,the treatment group on improving FEV₁ was better than control group（P<0.05）.（4）Comparison of IL-17,TGF-β₁:After the treatment,the treatment group obviously descended the level of IL-17,TGF-β₁ in serum（P<0.05）,the control group also reduced the level of IL-17,TGF-β₁.Comparison between two groups,the treatment group was better than the control group in reducind the the level of IL-17,TGF-β₁.Conclusion（s）: Combining Lijinfang with thiamethoxam bromide powder inhaler inhalation can better reduce the symptoms,improve pulmonary ventilation function,also can drop out the level of IL-17 and TGF-β₁ in serum,inhibiting the airway inflammation and delaying the airway remodeling in patients with COPD stable phase of lung qi deficiency syndrome.