The Association Between Single-nucleotide Polymorphisms Of Brain-derived Neurotrofic Factor And Post-stroke Depression In China

Objective: Recent studies have suggested that the polymorphisms of brain-derived neurotrophic factor(BDNF)is associated with some neurotrofic disorders and post-stroke depression(PSD).It's found that decreased serum BDNF levels is associated with PSD,but not with BDNF gene Val66 Met polymorphism.A research conducted a genome-wide association scan reveals that some genetic variants in the BDNF genes might regulate the level of serum BDNF in depressive patients.Further studies are needed to explore this debate.This study aimed to investigate whether there is a relationship between BDNF polymorphisms and PSD.Methods: A case-control study was performed with 305 PSD patients and 657 controls.All patients were evaluated with the Hamilton Rating Scale for Depression(HAMD)for depression severity,and PSD patients were diagnosed in accordance with DSM-V criteria.Genotyping was performed using polymerase chain reaction and high-resolution melt analysis for the 2 hypothesized SNPs.Genotype and allele frequencies of cases and controls were evaluated.Odds ratios were calculated for allele frequencies.Results: No significant difference was found between groups in the genotype distribution of rs6265 polymorphism.For rs2030324,we found that stroke was significantly associated with incident depression in participants with the TT genotype as compared with CC(OR 0.482,95% CI: 0.313-0.744).Minor allele(T)of rs2030324(P=0.004;OR=0.746,95%CI=[0.611,0.910])were found to be significantly associated with PSD.Conclusion: Our results suggested that rs2030324 in BDNF gene were significantly associated with post-stroke depression in Chinese population.And further studies are necessary to confirm this.