| Objective: Explore the influence factors resulting in normal D-dimer results in patients with acute VTE.Methods: According to the first D-dimer test after being hospitalized,patients were divided into normal D-dimer group and abnormal D-dimer group.Comparisons in basic datas,clinical features,risk factors,imaging and laboratory examinations were made between the two groups.Results: 898 patients were entered into the study,of which 113 were classified as normal D-dimer group and 785 were abnormal D-dimer group.There were no statistical differences between the two groups in age,sex and complication.There were statistical differences between the two groups in the time from onset of symptoms to D-dimer testing(9.7±6.5d vs 5.7±4.8d),high clinical probability(11.5% vs 6.2%),having been treated with anticoagulant therapy in 24h(17.7% vs 3.1%),previous PTE(19.5% vs 10.3%),extent and localization of PTE(68.1% vs 32.5%),venous valvular incompetence of lower extremity(16.8% vs 9.6%),hypercapnia(21.2% vs 11.75%),LDL-C(3.0±3.3mmol/L vs 2.8±0.3mmol/L).Binary regression analysis showed that the time from onset of symptoms to D-dimer testing,previous PTE,segmental and sub-segmental pulmonary artery embolism,having been treated with anticoagulant therapy in 24 h,elevated LDL-C levels were the independent influence factors resulting in normal D-dimer results in VTE.Conclusions: The time from onset of symptoms to D-dimer testing,segmental and sub-segmental pulmonary artery embolism,previous PTE,having been treated with anticoagulant therapy in 24 h,elevated LDL-C levels were the influence factors resulting in normal D-dimer results in VTE. |
