| Objective:Acute ST segment elevation myocardial infarction is based on coronary artery disease,coronary artery blood supply drastic reduction or interruption,The corresponding myocardium induced myocardial necrosis because of severe and lasting acute myocardial ischemia.Oxygen inhalation therapy(oxygen therapy)is one of the most commonly used methods of rescue and treatment,which was used more than 100 years.The guidelines for the diagnosis and treatment of acute ST segment elevation myocardial infarction 2015,report that all STEMI patients should be given oxygen therapy and ECG,monitored blood pressure and blood oxygen saturation immediately after hospitalized.However,many studies show that oxygen therapy can cause coronary artery blood vessel contraction,blood flow,oxygen free radical release and other adverse reactions.This study was a single-center,prospective and randomized controlled study.The purpose is observe whether the effect of STEMI patients with normal oxygen saturation(SaO2 >94%)were treated with oxygen therapy compared with control group.Method:Choice 60 STEMI Patients with SaO2 >94% admitted to Department of cardiology,The Second Hospital of Hebei Medical University from January 2015 to November 2015.The patients meeting inclusion criteria were randomly divided into two group: oxygen therapy group and control group.oxygen therapy group:given routine oxygen therapy,oxygen flow control in 2-3L/min.Control group: given low flow oxygen therapy,1L/min,from the placebo and control effect.All the selected patients were taken 3ml venous blood when admitted to the hospital and 3h after the oxygen therapy,used to test SOD?MDA? ET-1?CKMB?cTnI.The all were taken 3ml venous blood to test CKMB?cTnI.Data collection: measurement data was represented with mean + standard deviation,and count data was represented with the rate or the percentage.SPSS13.0 software package was used to process all datd,where P>0.05 was defined as statistical significance.count data groups were analyzed using chi-square test.T test or wilcoxon signed rank test was used to the inter-group comparison.Result: 1 Clinical data of two groups of patients:In this study,a total of 60 patients were screened and randomized with 30 cases in the oxygen therapy group and the control group respectively.Patients,who died of malignant arrhythmia of oxygen therapy group Within 12 h,were excluded,and finally 58 cases were successfully screened with 28 cases in the oxygen therapy group and 30 cases in the control group.No statistically significant difference was reported in terms of clinical features,intervention therapeutic situation.2 Comparison of two groups of patients with different experimental parameters 2.1 SOD content of the oxygen therapy group at admission(?U/L): 91.83 + 8.27,SOD content in the control group(?U/L): 88.79 + 7.32,there was no significant difference between the two groups: P=0.144;The review SOD content of the oxygen therapy group after 3h(?U/L):80.77 ± 6.73,The review SOD content of the control group(?U/L):84.50±7.17,The oxygen therapy group was lower than that in the control group,showing a statistically significant difference: P=0.046? 2.2 MDA content of the oxygen therapy group at admission(?mol/mg): 4.17±0.70,MDA content in the control group(?mol/mg): 3.96±0.48,there was no significant difference between the two groups: P=0.193;The review MDA content of the oxygen therapy group after 3h(?mol/mg):4.79 ± 0.70,The review MDA content of the control group(?mol/mg):4.46±0.45,The oxygen therapy group was lower than that in the control group,showing a statistically significant difference: P=0.041? 2.3 ET-1 content of the oxygen therapy group at admission(ng/L): 65.60±5.11,ET-1 content in the control group(ng/L): 64.98±5.09,there was no significant difference between the two groups: P=0.641;The review ET-1 content of the oxygen therapy group after 3h(ng/L):72.57 ± 4.73,The review ET-1 content of the control group(ng/L):69.95±4.58,The oxygen therapy group was lower than that in the control group,showing a statistically significant difference: P=0.036? 2.4 CKMB content of the oxygen therapy group at admission(U/L): 102.64±43.09,CKMB content in the control group(U/L): 83.29±43.11,there was no significant difference between the two groups: P=0.093;The review CKMB content of the oxygen therapy group after 3h(U/L):116.45 ± 41.34,The review CKMB content of the control group(U/L):91.50±43.61,The oxygen therapy group was lower than that in the control group,showing a statistically significant difference: P=0.030?The review CKMB content of the oxygen therapy group after 12h(U/L):188.33±37.81,The review CKMB content of the control group(U/L):164.50±41.14,The oxygen therapy group was lower than that in the control group,showing a statistically significant difference: P=0.026?CTnI content of the oxygen therapy group at admission(ng/mL): 15.58±7.81,CTnI content in the control group(ng/mL): 12.62±3.88,there was no significant difference between the two groups: P=0.078;The review CTnI content of the oxygen therapy group after 3h(ng/mL):17.02±7.88,The review CTnI content of the control group(ng/mL):13.53±3.96,The oxygen therapy group was lower than that in the control group,showing a statistically significant difference: P=0.042?The review CTnI content of the oxygen therapy group after 12h(ng/mL):29.65±7.81,The review CTnI content of the control group(ng/mL):25.38±4.49,The oxygen therapy group was lower than that in the control group,showing a statistically significant difference: P=0.015?Conclusion:Routine Oxygen Therapy to patients with acute ST segment elevation myocardial infarction with normal oxygen saturation(SaO2 >94%),may increase the damage of endothelium and myocardium.Therefore,patients with normal oxygen saturation are not recommended for routine oxygen therapy. |
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