The Research Of Taohong JianGu Concentrated Pill's Preparationprocess,Quality Standard And Anti-inflammatory And Analgesic Effect

Objective:Through the research of TaoHong JianGu concentrated pill's preparation process,quality standard and partial pharmacodynamics,summarize the best extraction technology,establish quality standard,and considering the anti-inflammation and analgesic action.Furthermore,provide the theoretical foundation for declaration,application,and promotion.Methods:By using orthogonal experiment to optimize the TaoHong JianGu concentrated pill's best alcohol extraction technology and best water extraction process,and the experiment study on the forming process,it is concluded that the preparation of a completely process.By thin-layer chromatography(TLC)method for qualitative identification of prescription medicines and general rule checks,including moisture,weight difference,time limit of soluble powder,microbial limit examination,and accelerated stability test.With xylene induced mouse ear swelling test and acetic acid twisting test respectively to investigate the anti-inflammatory effect and analgesic action.Result:The best preparation technology for TaoHong JianGu concentrated pill is that:Sanqi,Fuling,Xuejie,Yanhusuo,Zexie are crushed into fine powder(100 mesh sieve).Then Taoren,Honghua,Danggui,Chuanxiong heat with 8 times of 80%ethanol reflux extraction 2 times,extract 1 h each time.Then filtration,the filtrate decompression enrichment to relative density 1.18?1.20,obtain the extract?.Add 10 times water in the residuum from alcohol extraction liquid with six herbs such as Chishao,extracted three times,each time 2 h,concentrate the water decoction filtered enrichment,obtain extract?(relative density 1.18?1.20).After mixed extract?and extract?,mixed with the powder above,then put the liquid on pills plastic machine,plastic,drying,coating,products come out at the last.Quality standards research are including qualitative identification and the general principles check.Thin-layer chromatography(TLC)method's results show that with the reference substance chromatography corresponding to the position of the same color spots,negative control without interference;3 batches of samples of general principles of the examination results conform to the provisions,stability is good;Pharmacodynamics experiment results show that the preparation has certain anti-inflammatory and analgesic action,and non-toxic side effects.Conclusion:The preparation process of TaoHong JianGu concentrated pill is stable,reasonable and feasible;Thin layer chromatography(TLC)identification of medicinal materials is simple and easy,strong sensitivity,reproducibility and specificity.This pill has certain anti-inflammatory and analgesic effect,safe and non-toxic side effects.