Comparative Study Between Intravitreal Triamcinolone Acetonide And Oral Calcium Dobesilate For Macular Edema Due To Panretinal Photocoagulation

BackgroundStudies on therapy of macular edema by means of intravitreal triamcinolone acetonide and oral calcium dobesilate are frequently reported.Macular edema can be caused by fundus oculi disease,such as diabetic retinopathy and retinal vein occlusion.However,there aren't sufficient researches about therapy of macular edema due to panretinal photocoagulation.ObjectiveThis paper aims to investigate the differences of curative effects and security between two therapies in treating macular edema which is caused by panretinal photocoagulation: intravitreal triamcinolone acetonide and oral calcium dobesilate.MethodA study was performed on the clinical material of 72 patients(72 eyes in total)with macular edema due to panretinal photocoagulation under the treatment in our hosptial from January,2012 to January,2015.All of the 72 eyes were under treatment with panretinal photocoagulation because of serious diabetic retinopathy.After the treatment of panretinal photocoagulation,the patients got macular edema to varying degree,and some even acquired more serious macular edema than before.72 eyes were randomly divided into two groups,with respectively 36 eyes in each group: one is the Injection Group and the other is Oral Group.The former(patients)were treated with intravitreal injection of triamcinolone acetonide(0.025 ml,1mg);the latter(patients)took orally calcium dobesilate capsule.Best corrected visual acuity,central macular thickness,intraocular pressure and complications were observed before the treatment and 1 month,3 months and 6 months after treatment.ResultsThere were not obvious statistical significance on basic characters between two groups(P > 0.05).Intra-group comparison: after 1 month,3 months and 6 months of treatment,BCVA and CMT in the injection group were improved significantly as compared with that before treatment(P< 0.05);there were no significant differences in intraocular pressure(P > 0.05).After 1 month,3 months and 6 months of treatment,BCVA and CMT in the oral group showed no statistically significant differences before and after treatment(P > 0.05);no differences were found in intraocular pressure(P > 0.05).Intergroup comparison: after 1 month,3 months and 6 months of treatment,BCVA and CMT in the injection group were improved significantly than that in the oral group(P< 0.05),but there were no statistical differences in intraocular pressure between the two groups(P > 0.05).After treatment,there were not any severe ocular and physical complications in two groups.ConclusionsIn terms of improving BCVA and CMT of patients with macular edema due to panretinal photocoagulation,the injection of 1mg intravitreal triamcinolone acetonide was more efficient than oral calcium dobesilate.Both of them were safe and didn't cause any obvious side effects or severe complications.