| BackgroundDiabetes and tuberculosis is the clinical common disease and frequently-occurring disease,and both can influence each other.Diabetic patients with TB prevalence of four to eight times higher than the general population,two kinds of disease influence each other,and diabetic patients with low immunity,also is one of the main reasons for tuberculous disease,tuberculosis patients in part due to the poor glycemic control with diabetes mellitus affect curative effect and become recurrent pulmonary tuberculosis.Although there are a lot of past research on traditional Chinese medicine antibacterial activity against mycobacterium tuberculosis and reports,but also can not compare with chemical medication,the traditional Chinese medicine treatment of tuberculosis should still be on the basis of chemical drugs.Through the body's internal environment of regulate and improve the patient's general condition,improve the quality of life of patients,enhance the confidence of the patient to cure disease,become the real meaning of Chinese traditional medicine auxiliary treatment of tuberculosis.The Qi Jia Li Fei capsule is one of the "fifteen" national major project of science and technology achievements,become the state food and drug administration the first approval for anti-tuberculosis treatment of traditional Chinese medicine.The Qi Jia Li Fei capsule chemotherapy,insecticidal,and immune regulation,the literature has confirmed its adjuvant therapy,the retreatment and drug-resistant tuberculosis treated first can increase the rate of phlegm germ feminine changed,accelerate the lesions absorption and cavity closure,to speed up the clinical symptoms,improve immune function,have certain curative effect.But it is lack of the related report the related reports for the treatment of tuberculosis curative effect withdiabetes mellitus.ObjectiveThrough this study,to confirm the Qi Jia Li Fei capsule auxiliary treatment of recurrent pulmonary tuberculosis curative effect of the type 2 diabetes and can significantly improve the immune function,thus for clinical treatment of pulmonary tuberculosis drugs,to provide an effective auxiliary treatment for diabetes can accelerate the control of disease,reduce the economic burden and enhance patient confidence,improve patient quality of life.MethodsFrom October 2011 to October 2014,To pass through the bacteriology diagnosis of280 cases of recurrent pulmonary tuberculosis patients with type 2 diabetes in First Affiliated Hospital of Xinxiang Medical College,according to admission order were randomly divided into observation group and control group,140 cases each.Two groups of patients were 3SHRZE/9HRE plan anti-tuberculosis treatment,on this basis,the observation group was treated with the aid of Qi Jia Li Fei capsule.Contrast two groups of sputum negative conversion,lesions and cavity changes,TCM(traditional Chinese Medicine)syndromes and cellular immune function in aspects of differences.Observe two groups of glycosylated hemoglobin.Results1.The sputum negative conversion rate of sputum smear was 73.72%(101/137)and91.24%(125/137),respectively,at the end of the intensive phase and the end of the course of treatment,the control group were 57.97%(80/138)and 80.43%(111/138),the observation group were higher than the control group,the difference was statistically significant(P < 0.05).2.Strengthen at the end of the period and the end of treatment when the focus absorption markedly effective rate in the observation group were 68.61%(94/137),87.59%(120/137)and control group respectively for 45.65%(63/138),69.57%(96/138).Observation group were higher than control group,the differences were statistically significant(P < 0.05).3.Strengthen at the end of the period and period of treatment over temporal and spatial hole closure rate in the observation group were 21.9%(30/137)and 54.01%(74/137).Control group were 10.87%(15/138)of the,28.26%(39/138).Observation group were higher than control group,and the difference is statistically significant(P < 0.05).4.At the end of the treatment group and the control group,the total effective rate was89.78%(123/137),79.71%(110/138),the observation group was higher than the control group,the difference was statistically significant(P < 0.05).5.CD3+ of observation group and control group were significantly higher than that before treatment,the difference was statistically significant(P < 0.05);At the end of the treatment group and the control group CD3+,CD4+,CD4+/CD8+ were significantly higher than before treatment,the difference was statistically significant(P < 0.05).6.Observe group and control group test glycosylated hemoglobin was < 7%.ConclusionQi Jia Li Fei capsule in adjuvant treatment of retreated pulmonary tuberculosis with type 2 diabetes can improve the sputum negative conversion rate,focus significant efficiency and cavity closure rate can improve TCM syndrome efficacy and cellular immune function. |
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