A Laboratory Study On Coagulation And Hemostasis Function、Liver Function And Blood Cell Analysis In Patients With Chronic And Advanced Schistosomiasis、Chronic Hepatitis And Liver Cirrhosis

Objective: Investigate the coagulation and hemostasis function、fibrinolysis function、liver function、hepatic fibrosis and blood cell analysis in patients with chronic and advanced schistosomiasis、chronic hepatitis and liver cirrhosis aim to provide the relativity and regularity between each other and definite the clinical value to the disease diagnosis and assessment, treatment and prognosis of above laboratory indexes.Methods: Our samples were all gathered in Institute of parasites.Collect chronic and advanced schistosomiasis patients 50 each.And chronic hepatitis and liver cirrhosis patients 50 each(The age range from 35 to 70,average age57).50 health people without history of smoking and drinking and have normal diet 、sleep and examination indexes were chosed as the control group( The age range from 35 to 66,average age52). Extraction of venous blood on an empty stomach before all of the examinee were not take any medicine may affect coagulation function. Coagulation、 liver function and blood cell analysis test are completed in 4 hours. The venous blood of testing hemostasis function、fibrinolysis function、hepatic fibrosis will be separated plasma within 1 hour and save in-70℃.Result: 1 Compared with healthy controls, there was no significant difference in slow blood coagulation(PT、APTT、TT、Fg), there was significant difference in Anticoagulant function(AT-III、PC、PS), there was no statistical differences in Fibrinolytic indexes(PLG),there was significant difference in D- dimer level. Night blood group of PT, TT, Fg difference is significant,but there was no significant difference APTT,there was significant difference in anticoagulant and fibrinolytic function, Chronic hepatitis b and liver cirrhosis group of coagulant, anticoagulant and fibrinolytic function have significant difference; Slow blood group of patients with late blood group of patients in the comparison of PT and TT, there are significant differences and APTT and Fg there was no significant difference, the AT- and PC Ⅲhas a significant difference and there were no significant difference on the PS, D-dimer, PLG have significant difference; Slow blood and more blood coagulation function in patients with chronic hepatitis b is very significant difference, anticoagulant function, PLG and D- dimer level there was no significant difference; Late blood and liver cirrhosis comparing blood coagulation function in addition to the TT there was no significant difference between other difference is very significant, Anticoagulant and fibrinolytic function has significant difference; Chronic hepatitis b and liver cirrhosis group in the TT, because there was no significant differences in the comparison of Fg PT, APTT, there are significant differences, anticoagulant function and D- dimer have significant differences, PLG there was no significant difference.2 Slow blood, late blood and blood cells of patients with liver cirrhosis analysis project(WBC, RBC, Hb, PLT) compared with healthy controls to some extent,and cirrhosis of the group of the most obvious,with significant difference(P < 0.05). Chronic hepatitis b group of WBC, RBC, Hb decreased slightly compared with healthy controls, there was no statistically significant difference(P > 0.05), and PLT is lower than the control group, with significant difference(P = 0.001). Slow blood group and late blood WBC results are basically identical, no statistical difference(P > 0.05), and two groups of RBC, Hb and PLT differences statistically significant(P < 0.05). Slow blood group and the treatment of chronic hepatitis b group on blood analysis results with no statistical difference(P > 0.05).respectively for the treatment of chronic hepatitis b and cirrhosis of the liver, blood and liver cirrhosis late group, blood cell analysis the result difference had statistical significance(P ≦0.001).3 Compared with the healthy control, the projects(ALT, AST, TBIL, DBIL, propagated, GLB, GGT and ALP, AFP) of schistosomiasis(slow blood and late blood)are statistically significant(P < 0.05) except the total protein(TP). Compared between the later blood group and slow blood group, projects are statistically significant(P < 0.05) except TP and AFP. ALT, AST, TBIL, DBIL, GGT and ALP of the chronic hepatitis B group are significantly higher than the control(P < 0.05), but the projects TP, ALB, GLB are significantly lower than the control(P < 0.05), the mean value of AFP is significantly higher than those of the control group, but the rank is the same as that of the control group(P>0.05).The chronic hepatitis B group and the chronic blood group have statistical difference in all the liver function items(P<0.05). Compare with the control group, the cirrhosis group levels of ALT, AST, TBIL, DBIL, GLB, GGT, ALP increased significantly(P < 0.05), TP and ALB decreased significantly(P < 0.05),and AFP average was significantly higher than that of the control group, but the rank mean similar with the control(P > 0.05).Compared with the chronic hepatitis B group, the cirrhosis group is statistically significant(P<0.05) in the items except Glb, GGT, ALP,but significantly lower than the chronic hepatitis B group in ALT, AST, TBIL, DBIL, TP, ALB.There are significant differences in ALT, AST, ALB, GLB, GGT, between the liver cirrhosis group and late blood group(P<0.05), but other items are not significant(P>0.05).4 HA and LN of patients with chronic schistosomiasis is significantly higher than that of controls, P<0.05 and P<0.001, respectively, while PCIII and IVC have no significant difference between patients and controls, P>0.05. HA and LN of patients with advanced schistosomiasis are significantly higher than those of controls, P<0.001, while PCIII and IVC of patients with advanced schistosomiasis are nearly the same with controls, P>0.05. HA and PCIII of patients with advanced schistosomiasis are significantly higher than those of patients with chronic schistosomiasis, P<0.05, while LN and IVC have no significant difference between these two groups, P>0.05. HA, LN, PCIII and IVC of patients with chronic hepatitis B and patients with cirrhosis are significantly higher than those of controls, P<0. 01. PCIII of patients with cirrhosis is significantly higher than that of patients with chronic hepatitis B, P=0.007, while HA, LN and IVC have no significant difference between these two groups. HA, LN, PCIII and IVC of patients with chronic hepatitis B are significantly higher than those of patients with chronic schistosomiasis, P<0.001. HA, LN, PCIII and IVC of patients with cirrhosis are significantly higher than those of patients with advanced schistosomiasis, P<0.001.Conclusion: Coagulation, anticoagulation and fibrinolysis of patients with chronic schistosomiasis, with advanced schistosomiasis, with chronic hepatitis B, or with cirrhosis have changed to some extent. The number and counts of blood cells have also changed to some degree in these patients. There are also some degree of liver dysfunction and hepatic fibrosis in these patients. In conclusion, joint detection of these indicators have important clinical values in the diagnosis, treatment and prognosis of liver diseases.