Study On Chinese Medical Pattern Of Rheumatoid Arthritis Based On Multivariate Statistical Analysis

Objective: To establish Chinese Medical Pattern of Rheumatoid Arthritis,identify the main symptoms of every pattern and investigate the relationship of laboratory values with TCM Pattern of RA,we gathered the symptoms,signs and laboratory values of RA patients to analyze.Methods: This study observed 606 cases of RA patients of the Military General hospital of beijing PLA from 2012,may to 2014,may.The information contained patients' age,gender,symptoms,signs and laboratory values,such as ESR,PLT,RF,CRP and anti-CCP.Data analysis was made using multivariate Statistical Analysis to establish the pattern of RA.At last,to investigate the relationship between laboratory values and Pattern of RA.Results: 1)Patient age were from 21 years old to 70 years old in 606 patients,of them there were 135 males and 471 females.The males to females ratio was 1:3.5.Mean age was 44.13±13.74 years.The higher incidence was of middle-aged and old.There were 311 patients aged 45 through 59 years,that was highest proportion(51.32%).The shortest course was 6 months,and the longest was 492 months.Mean course of disease was 113.2±63.44 months.There were 188 patients with deformity of joints,163 females and 25 males.2)We can conclude 6 syndromes through cluster analysis and some proposal of the Task Force,such as syndrome of deficiency of both qi and blood,syndrome of combined cold-dampness,syndrome of combined dampness-heat,syndrome of yin deficiency of Liver and Kidney,syndrome of static blood blocking collaterals,syndrome of phlegm blocking collaterals.We concluded that factors and cardinal and minor symptoms by using logistic stepwise regression analysis and factor analysis.The cardinal symptoms of syndrome of deficiency of both qi and blood were short of bearth,the light color of tongue quality,weak pulse,and minor symptoms were weak vox,joint being well in warm environment,yellowish complexion,slimsy and deep pulse,disliking wind,the light color of finger nail.The cardinal symptoms of syndrome of combined cold-dampness were joint being well in warm environment,pain more serious due to cold exposure,feeling joint heavy,and minor symptoms were cold limbs,more serious on cloudy and rainy days,the light color of tongue quality,oedema legs.The cardinal symptoms of syndrome of combined dampness-heat were yellowish greasy tongue,joint swelling,hot jionts,and minor symptoms were red tongue,yellow tongue fur,bitter taste in mouth,deep-coloured urine,greasy fur of root of tongue.The cardinal symptoms of syndrome of yin deficiency of Liver and Kidney were soreness and weakness of waist and knees,night sweating,pulse being thready volant and Xian,and minor symptoms were cloudy vision,soreness waist,dryness eyes,crack tongue,weak four limbs,flushed face,dry and red tongue,red cheeks and decreased grip force.The cardinal symptoms of syndrome of static blood blocking collaterals were deep and stagnating pulse manifestation,dark red tongue,stabbing pain,and minor symptoms were violet base of tongue,joint swelling,dry mouth,limitation of motion.The cardinal symptoms of syndrome of phlegm blocking collaterals were limbs numbness,Xian-gliding pulse,white and greasy fur,and minor symptoms were coughing up sputum,limitation of motion,complexion without lustre,joint swelling,dark tongue and Xian-pulse.3)There were 312 cases with ESR-positive,and 328 cases with Platelet count-increase,and 392 cases with RF-positive,and 331 cases with CRP-positive,and 335 cases anti-CCP-positive.We analyzed the relationship between 5 laboratory values and Pattern of RA respectively by chi square test and found the difference that Platelet count-increase was distributed in each pattern.The difference was considered statistically significant(?2 =11.329,P=0.045<0.050).Other differences of laboratory values were not statistically significant.Conclusion: The study can analyze 6 syndromes with multivariate Statistical Analysis.The difference of Platelet count-increase in each pattern was considered statistically significant and the positive rate in syndrome of static blood blocking collaterals was highest.Differences that other 4 laboratory values were distributed in each pattern were not statistically significant.