| Background:Rheumatoid arthritis (rheumatoid arthritis, RA) is a systemic autoimmune disease involving multiple-joints. The disease can also have effects outside the joints and have seriously affected the patients on the quality of life the exact cause of RA is still not well understood so far. In Chinese literature of medicine, RA has long been associated with "BI-ZHENG", "HE-XI-FENG" and other symptoms similar to those recorded with RA. The use of Chinese medicine in the treatment of RA varies pending on the characteristics of pharmacology and practice of physicians according to their own clinical experience and diagnosis, which may result in syndrome differentiation and lack of standardization in the treatment of RA of TCM Syndrome Recently, a Chinese physician Jiao-Shu-De proposed the so-called "lame paralysis" In the treatment of RA. At present, the classification and differentiation of RA is utilized by Arthralgia. However, Arthralgia is not necessarily RA, even the reserve is true. Therefore, we examined the traditional Chinese medicine in patients with symptoms of RA and related information and summarized the clinical syndromes of RA type through statistical analysis. with hope to categorize different indicators and related syndromes, as well as correlation between them to further stimulate clinical research on RA's Syndrome and clinical therapy.Methods:The questionnaires based on clinical epidemiology were designed to collect the information on 401 cases of RA patients with clinical syndromes along with use of Chinese medicine from Southwest Hospital, Third Military Medical University, China. The following data were collected:health assessment questionnaire (HAQ) and visual score (VAS), blood samples taken at the same time, indirect Richard immunofluorescence anti-keratin antibodies (AKA); collection of erythrocyte sedimentation rate (ESR), rheumatoid factor (RF), C-reactive protein (CRP), anti-cyclic citrullinated peptide antibodies (CCP), glucose-6-phosphate isomerase (GPI), tumor necrosis factor (TNF-a) and the blood results. Statistical analysis using factor analysis, principal component and cluster analysis were carried out on the data to classify patients with syndrome information to reduce the dimensionality of characteristics after factors such as RF, AKA, CCP, ESR, WBC, PLT, GPI, TNF-α, VAS, etc. The differentiation related to the differences were also investigated in analysis.Result1.Classification of syndromes:the syndromes can be classified primarily as cold, heat, deficient three factors, which can be further sub-classified as six groups:cold syndrome, heat, deficiency, coldheat complex, deficient cold and asthenic fever. There were 58 cases of cold syndrome (14.5%),163 cases of coldheat complex (40.6%),18 cases of heat syndrome (4.5%),25 cases of deficiency (6.2%),85 cases of deficient cold and (21.1%),52 cases of asthenic fever (12.9%) according to the method from the data collected.2.Differentiation between the various indicators of:age, course of disease, VAS, HAQ, ESR, HGB, PLT by the homogeneity of variance test for homogeneity, which HAQ, HGB, PLT in the statistics between learning differences (P<0.05), according to the mean size of the syndrome in order to sort for:HAQ:heat (1.3264±0.6246)> coldheat complex (0.7285±0.5948)> asthenic fever (0.5793±0.5839)> Cold Syndrome (0.5474±0.6171)> Deficiency (0.5150±0.6082)> deficient cold (0.5088±0.5973); HGB:Cold (127.6000±12.4835)> asthenic fever (118.2188±9.7265)> coldheat complex (117.8312±9.2253)> deficient cold (116.1600±9.1253)> Heat (115.5000±8.3750)> Deficiency (113.5714±15.3878); PLT:heat (320.7500±35.6250)> Deficiency (218.2500±124.3750)> asthenic fever (212.4286±84.0816)> coldheat complex (186.5128±64.1049)> Cold (168.7727±66.0847)> deficient cold (165.5600±61.5120). Age, course of disease, VAS, ESR in the syndrome was no significant difference between (P> 0.05). In addition, CCP, RF, WBC variance missing, which in all RF Syndrome significant difference between (P<0.05), RF: Heat (495.8867±291.782)> Cold (342.7328±388.6141)> asthenic fever (175.7365±226.0908)> coldheat complex (164.2595±259.7283)> deficient cold (77.0024±232.740)> Deficiency (30.3600±274.5114); CCP, WBC Syndrome in no significant difference between (P> 0.05). AKA syndrome in the significant difference between (P <0.05), AKA positive rate:cold syndrome (34.48%)> mixed evidence chills and fever (22.70%)> asthenic fever (21.15%)> Deficiency (12.00%)> deficient cold (5.88%)> Heat Syndrome (5.56%); onset to spring up to the season, but statistically no significant difference (P> 0.05).Conclusion1.RA patients with the TCM Syndrome classification summarized as cold, heat, deficient three factors,which can be further divided into cold syndrome, heat, deficiency, coldheat complex, deficient cold and asthenic fever six syndromes.2. Reactiveness of RA ssociated with the TCM Syndrome, heat syndrome was particularly prevalent in the active phase and cold syndrome in stable phase.
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